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MCM8 (DNA helicase MCM8) is an enzyme. The public catalogues list it as a DNA repair gene, and the evidence so far is association rather than a proven role.
Component of the MCM8-MCM9 complex, which is involved in the repair of double-stranded DNA breaks (DBSs) and DNA interstrand cross-links (ICLs) by homologous recombination (HR). The MCM8-MCM9 complex is a 3'-5' DNA helicase and single-stranded (ss)DNA-stimulated ATPase which binds ssDNA in the presence of nucleoside triphosphates. Required for DNA resection by the MRE11-RAD50-NBN/NBS1 (MRN) complex by recruiting the MRN complex to the repair site and by promoting the complex nuclease activity.
Open Targets scores its association with cancer at 0.51 (direct and indirect evidence; datatypes literature 0.97, animal model 0.34, genetic association 0.62).
In plain words · MCM8 (DNA helicase MCM8) is an enzyme. The public catalogues list it as a DNA repair gene, and the evidence so far is association rather than a proven role.
MCM8 (DNA helicase MCM8) is an enzyme. The public catalogues list it as a DNA repair gene, and the evidence so far is association rather than a proven role.
Component of the MCM8-MCM9 complex, which is involved in the repair of double-stranded DNA breaks (DBSs) and DNA interstrand cross-links (ICLs) by homologous recombination (HR).
No product in this corpus aims at MCM8 yet. Inhibitors are shaped to fit the enzyme's active site so the reaction the cancer relies on stops.
First described 2001. Earliest sequence paper UniProt cites for the protein: Deloukas et al, Nature, 2001, "The DNA sequence and comparative analysis of human chromosome 20". Source.
Sources: HGNC HGNC:16147 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9UJA3 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000125885 (association with cancer (MONDO_0004992) 0.51; (GraphQL API, CC0))
Component of the MCM8-MCM9 complex, which is involved in the repair of double-stranded DNA breaks (DBSs) and DNA interstrand cross-links (ICLs) by homologous recombination (HR). The MCM8-MCM9 complex is a 3'-5' DNA helicase and single-stranded (ss)DNA-stimulated ATPase which binds ssDNA in the presence of nucleoside triphosphates. Required for DNA resection by the MRE11-RAD50-NBN/NBS1 (MRN) complex by recruiting the MRN complex to the repair site and by promoting the complex nuclease activity. Indirectly regulates the recruitment of downstream effector RAD51 to DNA damage sites including DBSs and ICLs, probably by regulating the localisation of the MNR complex. The MCM8-MCM9 complex is dispensable for DNA replication and S phase progression. May play a non-essential for DNA replication: may be involved in the activation of the prereplicative complex (pre-RC) during G(1) phase by recruiting CDC6 to the origin recognition complex (ORC). Location: Nucleus; Chromosome; Cytoplasm; Mitochondrion matrix (UniProt). Locus 20p12.3 (HGNC).
Query for this target: (TITLE:"MCM8" OR ABSTRACT:"MCM8" OR TITLE:"minichromosome maintenance 8 homologous recombination repair factor" OR ABSTRACT:"minichromosome maintenance 8 homologous recombination repair factor" OR TITLE:"DNA helicase MCM8" OR ABSTRACT:"DNA helicase MCM8" OR TITLE:"MGC4816" OR ABSTRACT:"MGC4816" OR TITLE:"MGC12866" OR ABSTRACT:"MGC12866" OR TITLE:"MGC119522" OR ABSTRACT:"MGC119522") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about MCM8, not a curated reading list.