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MCM8 (DNA helicase MCM8) is an enzyme. The public catalogues list it as a DNA repair gene, and the evidence so far is association rather than a proven role. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Component of the MCM8-MCM9 complex, which is involved in the repair of double-stranded DNA breaks (DBSs) and DNA interstrand cross-links (ICLs) by homologous recombination (HR). The MCM8-MCM9 complex is a 3'-5' DNA helicase and single-stranded (ss)DNA-stimulated ATPase which binds ssDNA in the presence of nucleoside triphosphates. Required for DNA resection by the MRE11-RAD50-NBN/NBS1 (MRN) complex by recruiting the MRN complex to the repair site and by promoting the complex nuclease activity. Indirectly regulates the recruitment of downstream effector RAD51 to DNA damage sites including DBSs and ICLs, probably by regulating the localisation of the MNR complex. The MCM8-MCM9 complex is dispensable for DNA replication and S phase progression. May play a non-essential for DNA replication: may be involved in the activation of the prereplicative complex (pre-RC) during G(1) phase by recruiting CDC6 to the origin recognition complex (ORC). Location: Nucleus; Chromosome; Cytoplasm; Mitochondrion matrix (UniProt). Locus 20p12.3 (HGNC).
No product in the corpus is aimed at this target yet.
No trial in the corpus names this target or one of its products.
No recorded escape route names this target.
No pathway diagram carries this target as a node.
No companion diagnostic in the registry measures this target.
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Query for this target: (TITLE:"MCM8" OR ABSTRACT:"MCM8" OR TITLE:"minichromosome maintenance 8 homologous recombination repair factor" OR ABSTRACT:"minichromosome maintenance 8 homologous recombination repair factor" OR TITLE:"DNA helicase MCM8" OR ABSTRACT:"DNA helicase MCM8" OR TITLE:"MGC4816" OR ABSTRACT:"MGC4816" OR TITLE:"MGC12866" OR ABSTRACT:"MGC12866" OR TITLE:"MGC119522" OR ABSTRACT:"MGC119522") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about MCM8, not a curated reading list.
The dossier as machine-readable JSON, at /api/v1/dossiers/mcm8.json: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/mcm8.json. Licence CC BY-NC 4.0.