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MAML1 (Mastermind-like protein 1) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role.
Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Enhances phosphorylation and proteolytic turnover of the NOTCH intracellular domain in the nucleus through interaction with CDK8.
Open Targets scores its association with cancer at 0.62 (direct and indirect evidence; datatypes literature 0.88, affected pathway 0.94, genetic association 0.00, somatic mutation 0.23).
In plain words · MAML1 (Mastermind-like protein 1) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role.
MAML1 (Mastermind-like protein 1) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role.
Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1.
No product in this corpus aims at MAML1 yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
First described 1996. Earliest sequence paper UniProt cites for the protein: Nagase et al, DNA Res, 1996, "Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1". Source.
Sources: HGNC HGNC:13632 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q92585 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000161021 (association with cancer (MONDO_0004992) 0.62; (GraphQL API, CC0))
Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Enhances phosphorylation and proteolytic turnover of the NOTCH intracellular domain in the nucleus through interaction with CDK8. Binds to CREBBP/CBP which promotes nucleosome acetylation at NOTCH enhancers and activates transcription. Induces phosphorylation and localisation of CREBBP to nuclear foci. Plays a role in haematopoietic development by regulating NOTCH-mediated lymphoid cell fate decisions. Location: Nucleus speckle (UniProt). Locus 5q35.3 (HGNC).
Query for this target: (TITLE:"MAML1" OR ABSTRACT:"MAML1" OR TITLE:"mastermind like transcriptional coactivator 1" OR ABSTRACT:"mastermind like transcriptional coactivator 1" OR TITLE:"Mastermind-like protein 1" OR ABSTRACT:"Mastermind-like protein 1" OR TITLE:"KIAA0200" OR ABSTRACT:"KIAA0200" OR TITLE:"Mam-1" OR ABSTRACT:"Mam-1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about MAML1, not a curated reading list.