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MAML1 (Mastermind-like protein 1) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Enhances phosphorylation and proteolytic turnover of the NOTCH intracellular domain in the nucleus through interaction with CDK8. Binds to CREBBP/CBP which promotes nucleosome acetylation at NOTCH enhancers and activates transcription. Induces phosphorylation and localisation of CREBBP to nuclear foci. Plays a role in haematopoietic development by regulating NOTCH-mediated lymphoid cell fate decisions. Location: Nucleus speckle (UniProt). Locus 5q35.3 (HGNC).
No product in the corpus is aimed at this target yet.
No trial in the corpus names this target or one of its products.
No recorded escape route names this target.
No pathway diagram carries this target as a node.
No companion diagnostic in the registry measures this target.
No model entry for this target yet; check the cancer entries on the models page.
No open questions recorded for this target yet. Suggest one.
Query for this target: (TITLE:"MAML1" OR ABSTRACT:"MAML1" OR TITLE:"mastermind like transcriptional coactivator 1" OR ABSTRACT:"mastermind like transcriptional coactivator 1" OR TITLE:"Mastermind-like protein 1" OR ABSTRACT:"Mastermind-like protein 1" OR TITLE:"KIAA0200" OR ABSTRACT:"KIAA0200" OR TITLE:"Mam-1" OR ABSTRACT:"Mam-1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about MAML1, not a curated reading list.
The dossier as machine-readable JSON, at /api/v1/dossiers/maml1.json: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/maml1.json. Licence CC BY-NC 4.0.