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LTB (Lymphotoxin-beta) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Diffuse large B-cell lymphoma.
Cytokine that binds to LTBR/TNFRSF3. May play a specific role in immune response regulation. Provides the membrane anchor for the attachment of the heterotrimeric complex to the cell surface.
CIViC holds 1 clinical evidence item and 0 assertions across 1 variant.
In plain words · LTB (Lymphotoxin-beta) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Diffuse large B-cell lymphoma.
LTB (Lymphotoxin-beta) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Diffuse large B-cell lymphoma.
Cytokine that binds to LTBR/TNFRSF3. May play a specific role in immune response regulation.
No product in this corpus aims at LTB yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the role biomarker; HPA finds the RNA group enriched, which says where the protein sits but not whether the tumour differs from normal tissue. HPA LTB: RNA group enriched (intestine 62 nTPM, lymphoid tissue 220 nTPM); no normal tissue stained high. Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Lymphoma); Open Targets associates it with 0 specific cancer types at or above 0.5. (No rule of scripts/fetch-target-specificity.ts fired.)
Sources: Human Protein Atlas LTB tissue; Open Targets ENSG00000227507 associations
First described 1993. Earliest sequence paper UniProt cites for the protein: Browning J.L. et al, Cell, 1993, "Lymphotoxin beta, a novel member of the TNF family that forms a heteromeric complex with lymphotoxin on the cell surface". Source.
Sources: HGNC HGNC:6711 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q06643 (protein name, function text, keywords and locations (REST API)); CIViC gene LTB (1 evidence items, 0 assertions, 1 variants; diseases: Diffuse Large B-cell Lymphoma (GraphQL API, CC0))
Cytokine that binds to LTBR/TNFRSF3. May play a specific role in immune response regulation. Provides the membrane anchor for the attachment of the heterotrimeric complex to the cell surface. Isoform 2 is probably non-functional. Location: Membrane (UniProt). Locus 6p21.33 (HGNC).
RNA: group enriched (intestine 62 nTPM, lymphoid tissue 220 nTPM), detected in many normal tissues.
No normal tissue stained high; medium in Lymph node, Tonsil.
No cancer stained high; medium in carcinoid, cervical cancer, colorectal cancer, endometrial cancer.
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"LTB" OR ABSTRACT:"LTB" OR TITLE:"lymphotoxin beta" OR ABSTRACT:"lymphotoxin beta" OR TITLE:"Lymphotoxin-beta" OR ABSTRACT:"Lymphotoxin-beta" OR TITLE:"p33" OR ABSTRACT:"p33" OR TITLE:"TNFSF3" OR ABSTRACT:"TNFSF3") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about LTB, not a curated reading list.