{"entity":{"id":"ltb","kind":"target","name":"LTB","aka":["lymphotoxin beta","Lymphotoxin-beta","p33","TNFSF3"],"tldr":"LTB (Lymphotoxin-beta) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Diffuse large B-cell lymphoma.","summary":"Cytokine that binds to LTBR/TNFRSF3. May play a specific role in immune response regulation. Provides the membrane anchor for the attachment of the heterotrimeric complex to the cell surface.\n\nCIViC holds 1 clinical evidence item and 0 assertions across 1 variant.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:6711","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6711"},{"label":"UniProt Q06643","url":"https://www.uniprot.org/uniprotkb/Q06643/entry"},{"label":"NCBI Gene 4050","url":"https://www.ncbi.nlm.nih.gov/gene/4050"},{"label":"Ensembl ENSG00000227507","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000227507"}],"tags":["cancer-genes-wave"],"related":["civic"],"cancers":["dlbcl"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC holds 1 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"LTB","role":["biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:6711","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6711","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q06643","url":"https://www.uniprot.org/uniprotkb/Q06643/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene LTB","url":"https://civicdb.org/features/3342","note":"1 evidence items, 0 assertions, 1 variants; diseases: Diffuse Large B-cell Lymphoma (GraphQL API, CC0)"}],"distribution":"one-type","specificityNote":"Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the role biomarker; HPA finds the RNA group enriched, which says where the protein sits but not whether the tumour differs from normal tissue. HPA LTB: RNA group enriched (intestine 62 nTPM, lymphoid tissue 220 nTPM); no normal tissue stained high. Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Lymphoma); Open Targets associates it with 0 specific cancer types at or above 0.5. (No rule of scripts/fetch-target-specificity.ts fired.)","specificitySources":[{"label":"Human Protein Atlas LTB tissue","url":"https://www.proteinatlas.org/ENSG00000227507-LTB/tissue","note":"RNA tissue and blood lineage specificity, normal tissue antibody staining (version 25.1, CC BY-SA 3.0)"},{"label":"Open Targets ENSG00000227507 associations","url":"https://platform.opentargets.org/target/ENSG00000227507/associations","note":"cancer associations at or above 0.5 (CC0)"}],"hgnc":"HGNC:6711","ensembl":"ENSG00000227507","uniprot":"Q06643","entrez":"4050","firstDescribed":1993,"firstDescribedBasis":"sequence","firstDescribedNote":"Earliest sequence paper UniProt cites for the protein: Browning J.L. et al, Cell, 1993, \"Lymphotoxin beta, a novel member of the TNF family that forms a heteromeric complex with lymphotoxin on the cell surface\".","firstDescribedSource":"https://pubmed.ncbi.nlm.nih.gov/7916655/","biology":"Cytokine that binds to LTBR/TNFRSF3. May play a specific role in immune response regulation. Provides the membrane anchor for the attachment of the heterotrimeric complex to the cell surface. Isoform 2 is probably non-functional. Location: Membrane (UniProt). Locus 6p21.33 (HGNC).","whereFound":["Diffuse large B-cell lymphoma: CIViC evidence names this disease"],"targetClass":"other","prevalence":[]},"route":"/targets/ltb/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"}],"cancer":[{"id":"dlbcl","kind":"cancer","name":"Diffuse large B-cell lymphoma","route":"/cancers/dlbcl/"}]}}