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LRFN2 (Leucine-rich repeat and fibronectin type-III domain-containing protein 2) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Promotes neurite outgrowth in hippocampal neurons. Enhances the cell surface expression of 2 NMDA receptor subunits GRIN1 and GRIN2A. May play a role in redistributing DLG4 to the cell periphery.
Open Targets scores its association with cancer at 0.53 (direct and indirect evidence; datatypes literature 0.81, animal model 0.55, genetic association 0.65).
In plain words · LRFN2 (Leucine-rich repeat and fibronectin type-III domain-containing protein 2) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
LRFN2 (Leucine-rich repeat and fibronectin type-III domain-containing protein 2) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Promotes neurite outgrowth in hippocampal neurons. Enhances the cell surface expression of 2 NMDA receptor subunits GRIN1 and GRIN2A.
No product in this corpus aims at LRFN2 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 1999. Earliest sequence paper UniProt cites for the protein: Nagase et al, DNA Res, 1999, "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". Source.
Sources: HGNC HGNC:21226 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9ULH4 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000156564 (association with cancer (MONDO_0004992) 0.53; (GraphQL API, CC0))
Promotes neurite outgrowth in hippocampal neurons. Enhances the cell surface expression of 2 NMDA receptor subunits GRIN1 and GRIN2A. May play a role in redistributing DLG4 to the cell periphery. Location: Membrane; Synapse; Postsynaptic cell membrane (UniProt). Locus 6p21.2-p21.1 (HGNC).
Query for this target: (TITLE:"LRFN2" OR ABSTRACT:"LRFN2" OR TITLE:"leucine rich repeat and fibronectin type III domain containing 2" OR ABSTRACT:"leucine rich repeat and fibronectin type III domain containing 2" OR TITLE:"Leucine-rich repeat and fibronectin type-III domain-containing protein 2" OR ABSTRACT:"Leucine-rich repeat and fibronectin type-III domain-containing protein 2" OR TITLE:"FIGLER2" OR ABSTRACT:"FIGLER2" OR TITLE:"KIAA1246" OR ABSTRACT:"KIAA1246" OR TITLE:"SALM1" OR ABSTRACT:"SALM1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about LRFN2, not a curated reading list.