{"entity":{"id":"lrfn2","kind":"target","name":"LRFN2","aka":["leucine rich repeat and fibronectin type III domain containing 2","Leucine-rich repeat and fibronectin type-III domain-containing protein 2","FIGLER2","KIAA1246","SALM1"],"tldr":"LRFN2 (Leucine-rich repeat and fibronectin type-III domain-containing protein 2) is a gene. In the public catalogues the evidence so far is association rather than a proven role.","summary":"Promotes neurite outgrowth in hippocampal neurons. Enhances the cell surface expression of 2 NMDA receptor subunits GRIN1 and GRIN2A. May play a role in redistributing DLG4 to the cell periphery.\n\nOpen Targets scores its association with cancer at 0.53 (direct and indirect evidence; datatypes literature 0.81, animal model 0.55, genetic association 0.65).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:21226","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:21226"},{"label":"UniProt Q9ULH4","url":"https://www.uniprot.org/uniprotkb/Q9ULH4/entry"},{"label":"NCBI Gene 57497","url":"https://www.ncbi.nlm.nih.gov/gene/57497"},{"label":"Ensembl ENSG00000156564","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000156564"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"LRFN2","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:21226","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:21226","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q9ULH4","url":"https://www.uniprot.org/uniprotkb/Q9ULH4/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000156564","url":"https://platform.opentargets.org/target/ENSG00000156564/associations","note":"association with cancer (MONDO_0004992) 0.53;  (GraphQL API, CC0)"}],"specificitySources":[],"hgnc":"HGNC:21226","ensembl":"ENSG00000156564","uniprot":"Q9ULH4","entrez":"57497","firstDescribed":1999,"firstDescribedBasis":"sequence","firstDescribedNote":"Earliest sequence paper UniProt cites for the protein: Nagase et al, DNA Res, 1999, \"Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro\".","firstDescribedSource":"https://pubmed.ncbi.nlm.nih.gov/10574462/","biology":"Promotes neurite outgrowth in hippocampal neurons. Enhances the cell surface expression of 2 NMDA receptor subunits GRIN1 and GRIN2A. May play a role in redistributing DLG4 to the cell periphery. Location: Membrane; Synapse; Postsynaptic cell membrane (UniProt). Locus 6p21.2-p21.1 (HGNC).","whereFound":[],"targetClass":"other","prevalence":[]},"route":"/targets/lrfn2/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}]}}