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LAMC1 (Laminin subunit gamma-1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organisation of cells into tissues during embryonic development by interacting with other extracellular matrix components. As a subunit of laminin-1 (also known as laminin-111 or EHS laminin), it is involved in the stimulation of agrin-induced receptor clustering through a MuSK-independent pathway.
Open Targets scores its association with cancer at 0.56 (direct and indirect evidence; datatypes literature 0.96, animal model 0.44, genetic association 0.70).
In plain words · LAMC1 (Laminin subunit gamma-1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
LAMC1 (Laminin subunit gamma-1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organisation of cells into tissues during embryonic development by interacting with other extracellular matrix components.
No product in this corpus aims at LAMC1 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 1988. Earliest sequence paper UniProt cites for the protein: Pikkarainen et al, J. Biol. Chem, 1988, "Human laminin B2 chain. Comparison of the complete amino acid sequence with the B1 chain reveals variability in sequence homology between different structural domains". Source.
Sources: HGNC HGNC:6492 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P11047 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000135862 (association with cancer (MONDO_0004992) 0.56; (GraphQL API, CC0))
Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organisation of cells into tissues during embryonic development by interacting with other extracellular matrix components. As a subunit of laminin-1 (also known as laminin-111 or EHS laminin), it is involved in the stimulation of agrin-induced receptor clustering through a MuSK-independent pathway. Location: Secreted, extracellular space, extracellular matrix, basement membrane (UniProt). Locus 1q25.3 (HGNC).
Query for this target: (TITLE:"LAMC1" OR ABSTRACT:"LAMC1" OR TITLE:"laminin subunit gamma 1" OR ABSTRACT:"laminin subunit gamma 1" OR TITLE:"Laminin subunit gamma-1" OR ABSTRACT:"Laminin subunit gamma-1" OR TITLE:"LAMB2" OR ABSTRACT:"LAMB2") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about LAMC1, not a curated reading list.