{"entity":{"id":"lamc1","kind":"target","name":"LAMC1","aka":["laminin subunit gamma 1","Laminin subunit gamma-1","LAMB2"],"tldr":"LAMC1 (Laminin subunit gamma-1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.","summary":"Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organisation of cells into tissues during embryonic development by interacting with other extracellular matrix components. As a subunit of laminin-1 (also known as laminin-111 or EHS laminin), it is involved in the stimulation of agrin-induced receptor clustering through a MuSK-independent pathway.\n\nOpen Targets scores its association with cancer at 0.56 (direct and indirect evidence; datatypes literature 0.96, animal model 0.44, genetic association 0.70).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:6492","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6492"},{"label":"UniProt P11047","url":"https://www.uniprot.org/uniprotkb/P11047/entry"},{"label":"NCBI Gene 3915","url":"https://www.ncbi.nlm.nih.gov/gene/3915"},{"label":"Ensembl ENSG00000135862","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000135862"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"LAMC1","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:6492","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6492","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P11047","url":"https://www.uniprot.org/uniprotkb/P11047/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000135862","url":"https://platform.opentargets.org/target/ENSG00000135862/associations","note":"association with cancer (MONDO_0004992) 0.56;  (GraphQL API, CC0)"}],"specificitySources":[],"hgnc":"HGNC:6492","ensembl":"ENSG00000135862","uniprot":"P11047","entrez":"3915","firstDescribed":1988,"firstDescribedBasis":"sequence","firstDescribedNote":"Earliest sequence paper UniProt cites for the protein: Pikkarainen et al, J. Biol. Chem, 1988, \"Human laminin B2 chain. Comparison of the complete amino acid sequence with the B1 chain reveals variability in sequence homology between different structural domains\".","firstDescribedSource":"https://pubmed.ncbi.nlm.nih.gov/3360804/","biology":"Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organisation of cells into tissues during embryonic development by interacting with other extracellular matrix components. As a subunit of laminin-1 (also known as laminin-111 or EHS laminin), it is involved in the stimulation of agrin-induced receptor clustering through a MuSK-independent pathway. Location: Secreted, extracellular space, extracellular matrix, basement membrane (UniProt). Locus 1q25.3 (HGNC).","whereFound":[],"targetClass":"other","prevalence":[]},"route":"/targets/lamc1/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}]}}