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KLHL14 (Kelch-like protein 14) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Diffuse large B-cell lymphoma.
UniProt has no function text for Q9P2G3; HGNC names it "kelch like family member 14".
CIViC holds 1 clinical evidence item and 0 assertions across 1 variant.
In plain words · KLHL14 (Kelch-like protein 14) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Diffuse large B-cell lymphoma.
KLHL14 (Kelch-like protein 14) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Diffuse large B-cell lymphoma.
UniProt has no function text for Q9P2G3; HGNC names it "kelch like family member 14". Location: Cytoplasm, cytosol; Endoplasmic reticulum membrane (UniProt).
No product in this corpus aims at KLHL14 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the role biomarker; HPA finds the RNA tissue enhanced, which says where the protein sits but not whether the tumour differs from normal tissue. HPA KLHL14: RNA tissue enhanced (lymphoid tissue 8 nTPM, seminal vesicle 12 nTPM, thyroid gland 13 nTPM); blood lineage lineage enriched (B-cells 11 nTPM); no normal tissue stained high; highest cancer staining melanoma (11 of 12 high). Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Lymphoma); Open Targets associates it with 0 specific cancer types at or above 0.5. (No rule of scripts/fetch-target-specificity.ts fired.)
Sources: Human Protein Atlas KLHL14 tissue; Open Targets ENSG00000197705 associations
First described 2000. Earliest sequence paper UniProt cites for the protein: Nagase et al, DNA Res, 2000, "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro". Source.
Sources: HGNC HGNC:29266 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9P2G3 (protein name, function text, keywords and locations (REST API)); CIViC gene KLHL14 (1 evidence items, 0 assertions, 1 variants; diseases: Diffuse Large B-cell Lymphoma (GraphQL API, CC0))
UniProt has no function text for Q9P2G3; HGNC names it "kelch like family member 14". Location: Cytoplasm, cytosol; Endoplasmic reticulum membrane (UniProt). Locus 18q12.1 (HGNC).
RNA: tissue enhanced (lymphoid tissue 8 nTPM, seminal vesicle 12 nTPM, thyroid gland 13 nTPM), detected in some normal tissues. Blood: lineage enriched (B-cells 11 nTPM).
No normal tissue stained high.
RNA group enriched: Ovary Serous Cystadenocarcinoma 27 pTPM, Thyroid Carcinoma 12 pTPM, Uterine Corpus Endometrial Carcinoma 13 pTPM.
Medium only: cervical cancer.
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"KLHL14" OR ABSTRACT:"KLHL14" OR TITLE:"kelch like family member 14" OR ABSTRACT:"kelch like family member 14" OR TITLE:"Kelch-like protein 14" OR ABSTRACT:"Kelch-like protein 14" OR TITLE:"KIAA1384" OR ABSTRACT:"KIAA1384") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about KLHL14, not a curated reading list.