{"entity":{"id":"klhl14","kind":"target","name":"KLHL14","aka":["kelch like family member 14","Kelch-like protein 14","KIAA1384"],"tldr":"KLHL14 (Kelch-like protein 14) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Diffuse large B-cell lymphoma.","summary":"UniProt has no function text for Q9P2G3; HGNC names it \"kelch like family member 14\".\n\nCIViC holds 1 clinical evidence item and 0 assertions across 1 variant.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:29266","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:29266"},{"label":"UniProt Q9P2G3","url":"https://www.uniprot.org/uniprotkb/Q9P2G3/entry"},{"label":"NCBI Gene 57565","url":"https://www.ncbi.nlm.nih.gov/gene/57565"},{"label":"Ensembl ENSG00000197705","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000197705"}],"tags":["cancer-genes-wave"],"related":["civic"],"cancers":["dlbcl"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC holds 1 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"KLHL14","role":["biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:29266","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:29266","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q9P2G3","url":"https://www.uniprot.org/uniprotkb/Q9P2G3/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene KLHL14","url":"https://civicdb.org/features/13880","note":"1 evidence items, 0 assertions, 1 variants; diseases: Diffuse Large B-cell Lymphoma (GraphQL API, CC0)"}],"distribution":"one-type","specificityNote":"Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the role biomarker; HPA finds the RNA tissue enhanced, which says where the protein sits but not whether the tumour differs from normal tissue. HPA KLHL14: RNA tissue enhanced (lymphoid tissue 8 nTPM, seminal vesicle 12 nTPM, thyroid gland 13 nTPM); blood lineage lineage enriched (B-cells 11 nTPM); no normal tissue stained high; highest cancer staining melanoma (11 of 12 high). Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Lymphoma); Open Targets associates it with 0 specific cancer types at or above 0.5. (No rule of scripts/fetch-target-specificity.ts fired.)","specificitySources":[{"label":"Human Protein Atlas KLHL14 tissue","url":"https://www.proteinatlas.org/ENSG00000197705-KLHL14/tissue","note":"RNA tissue and blood lineage specificity, normal tissue antibody staining (version 25.1, CC BY-SA 3.0)"},{"label":"Open Targets ENSG00000197705 associations","url":"https://platform.opentargets.org/target/ENSG00000197705/associations","note":"cancer associations at or above 0.5 (CC0)"}],"hgnc":"HGNC:29266","ensembl":"ENSG00000197705","uniprot":"Q9P2G3","entrez":"57565","firstDescribed":2000,"firstDescribedBasis":"sequence","firstDescribedNote":"Earliest sequence paper UniProt cites for the protein: Nagase et al, DNA Res, 2000, \"Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro\".","firstDescribedSource":"https://pubmed.ncbi.nlm.nih.gov/10718198/","biology":"UniProt has no function text for Q9P2G3; HGNC names it \"kelch like family member 14\". Location: Cytoplasm, cytosol; Endoplasmic reticulum membrane (UniProt). Locus 18q12.1 (HGNC).","whereFound":["Diffuse large B-cell lymphoma: CIViC evidence names this disease"],"targetClass":"other","prevalence":[]},"route":"/targets/klhl14/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"}],"cancer":[{"id":"dlbcl","kind":"cancer","name":"Diffuse large B-cell lymphoma","route":"/cancers/dlbcl/"}]}}