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KLF2 (Krueppel-like factor 2) is a protein that switches other genes on and off. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Diffuse large B-cell lymphoma.
Transcription factor that binds to the CACCC box in the promoter of target genes such as HBB/beta globin or NOV and activates their transcription. Might be involved in transcriptional regulation by modulating the binding of the RARA nuclear receptor to RARE DNA elements.
CIViC holds 1 clinical evidence item and 0 assertions across 1 variant. Open Targets scores its association with cancer at 0.53 (direct and indirect evidence; datatypes literature 0.98, genetic association 0.66).
In plain words · KLF2 (Krueppel-like factor 2) is a protein that switches other genes on and off. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Diffuse large B-cell lymphoma.
KLF2 (Krueppel-like factor 2) is a protein that switches other genes on and off. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Diffuse large B-cell lymphoma.
Transcription factor that binds to the CACCC box in the promoter of target genes such as HBB/beta globin or NOV and activates their transcription.
No product in this corpus aims at KLF2 yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
Broadly expressed or essential: HPA finds the RNA at low tissue specificity; a medicine acting on the wild-type protein would expose normal tissue too. HPA KLF2: RNA low tissue specificity; high antibody staining in 9 normal tissues; highest cancer staining melanoma (1 of 9 high). Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Lymphoma); Open Targets associates it with 0 specific cancer types at or above 0.5. (Rule 7 of scripts/fetch-target-specificity.ts.)
Sources: Human Protein Atlas KLF2 tissue; Open Targets ENSG00000127528 associations
First described 1999. Earliest sequence paper UniProt cites for the protein: Kozyrev S.V. et al, FEBS Lett, 1999, "Structure of the human CpG-island-containing lung Kruppel-like factor (LKLF) gene and its location in chromosome 19p13.11-13 locus". Source.
Sources: HGNC HGNC:6347 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9Y5W3 (protein name, function text, keywords and locations (REST API)); CIViC gene KLF2 (1 evidence items, 0 assertions, 1 variants; diseases: Diffuse Large B-cell Lymphoma (GraphQL API, CC0)); Open Targets ENSG00000127528 (association with cancer (MONDO_0004992) 0.53; (GraphQL API, CC0))
Transcription factor that binds to the CACCC box in the promoter of target genes such as HBB/beta globin or NOV and activates their transcription. Might be involved in transcriptional regulation by modulating the binding of the RARA nuclear receptor to RARE DNA elements. Location: Nucleus (UniProt). Locus 19p13.11 (HGNC).
RNA: low tissue specificity, detected in many normal tissues.
Medium: Appendix, Bone marrow, Bronchus, Caudate, Cerebellum, Colon, Duodenum, Endometrium.
Medium only: breast cancer, carcinoid, endometrial cancer, glioma.
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"KLF2" OR ABSTRACT:"KLF2" OR TITLE:"KLF transcription factor 2" OR ABSTRACT:"KLF transcription factor 2" OR TITLE:"Krueppel-like factor 2" OR ABSTRACT:"Krueppel-like factor 2") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about KLF2, not a curated reading list.
Shares Marginal zone lymphoma, CIViC, Diffuse large B-cell lymphoma, Open Targets Platform.
Shares Marginal zone lymphoma, CIViC, Diffuse large B-cell lymphoma, Open Targets Platform.
Shares Marginal zone lymphoma, CIViC, Diffuse large B-cell lymphoma, Open Targets Platform.
Shares Marginal zone lymphoma, Diffuse large B-cell lymphoma, Open Targets Platform.
Shares Marginal zone lymphoma, Diffuse large B-cell lymphoma.
Shares Marginal zone lymphoma, CIViC, Open Targets Platform.
Shares Marginal zone lymphoma, Diffuse large B-cell lymphoma.
Shares Marginal zone lymphoma, Diffuse large B-cell lymphoma.