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KIF23 (Kinesin-like protein KIF23) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Hepatocellular carcinoma.
Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signalling required for the myosin contractile ring formation during the cell cycle cytokinesis. Essential for cytokinesis in Rho-mediated signalling. Required for the localisation of ECT2 to the central spindle.
CIViC holds 1 clinical evidence item and 0 assertions across 1 variant.
In plain words · KIF23 (Kinesin-like protein KIF23) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Hepatocellular carcinoma.
KIF23 (Kinesin-like protein KIF23) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Hepatocellular carcinoma.
Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signalling required for the myosin contractile ring formation during the cell cycle cytokinesis.
No product in this corpus aims at KIF23 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
Broadly expressed or essential: HPA lists KIF23 among essential proteins; a medicine acting on the wild-type protein would expose normal tissue too. HPA KIF23: RNA tissue enhanced (bone marrow 20 nTPM, lymphoid tissue 15 nTPM); blood lineage group enriched (granulocytes 5 nTPM, monocytes 1 nTPM, T-cells 1 nTPM); no normal tissue stained high; highest cancer staining lymphoma (10 of 12 high). Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Hepatocellular carcinoma); Open Targets associates it with 0 specific cancer types at or above 0.5. (Rule 7 of scripts/fetch-target-specificity.ts.)
Sources: Human Protein Atlas KIF23 tissue; Open Targets ENSG00000137807 associations
First described 1992. Earliest sequence paper UniProt cites for the protein: Nislow et al, Nature, 1992, "A plus-end-directed motor enzyme that moves antiparallel microtubules in vitro localizes to the interzone of mitotic spindles". Source.
Sources: HGNC HGNC:6392 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q02241 (protein name, function text, keywords and locations (REST API)); CIViC gene KIF23 (1 evidence items, 0 assertions, 1 variants; diseases: Hepatocellular Carcinoma (GraphQL API, CC0))
Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signalling required for the myosin contractile ring formation during the cell cycle cytokinesis. Essential for cytokinesis in Rho-mediated signalling. Required for the localisation of ECT2 to the central spindle. Plus-end-directed motor enzyme that moves antiparallel microtubules in vitro. Location: Nucleus; Cytoplasm, cytoskeleton, spindle; Midbody, Midbody ring; Midbody (UniProt). Locus 15q23 (HGNC).
RNA: tissue enhanced (bone marrow 20 nTPM, lymphoid tissue 15 nTPM), detected in many normal tissues. Blood: group enriched (granulocytes 5 nTPM, monocytes 1 nTPM, T-cells 1 nTPM).
No normal tissue stained high.
HPA KIF23 tissue · HPA KIF23 pathology · HPA protein class: Essential proteins
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"KIF23" OR ABSTRACT:"KIF23" OR TITLE:"kinesin family member 23" OR ABSTRACT:"kinesin family member 23" OR TITLE:"Kinesin-like protein KIF23" OR ABSTRACT:"Kinesin-like protein KIF23" OR TITLE:"MKLP1" OR ABSTRACT:"MKLP1" OR TITLE:"MKLP-1" OR ABSTRACT:"MKLP-1" OR TITLE:"KNSL5" OR ABSTRACT:"KNSL5") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about KIF23, not a curated reading list.