{"entity":{"id":"kif23","kind":"target","name":"KIF23","aka":["kinesin family member 23","Kinesin-like protein KIF23","MKLP1","MKLP-1","KNSL5"],"tldr":"KIF23 (Kinesin-like protein KIF23) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Hepatocellular carcinoma.","summary":"Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signalling required for the myosin contractile ring formation during the cell cycle cytokinesis. Essential for cytokinesis in Rho-mediated signalling. Required for the localisation of ECT2 to the central spindle.\n\nCIViC holds 1 clinical evidence item and 0 assertions across 1 variant.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:6392","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6392"},{"label":"UniProt Q02241","url":"https://www.uniprot.org/uniprotkb/Q02241/entry"},{"label":"NCBI Gene 9493","url":"https://www.ncbi.nlm.nih.gov/gene/9493"},{"label":"Ensembl ENSG00000137807","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000137807"}],"tags":["cancer-genes-wave"],"related":["civic"],"cancers":["hcc"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC holds 1 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"KIF23","role":["biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:6392","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6392","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q02241","url":"https://www.uniprot.org/uniprotkb/Q02241/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene KIF23","url":"https://civicdb.org/features/7502","note":"1 evidence items, 0 assertions, 1 variants; diseases: Hepatocellular Carcinoma (GraphQL API, CC0)"}],"specificity":"broadly-expressed","distribution":"one-type","specificityNote":"Broadly expressed or essential: HPA lists KIF23 among essential proteins; a medicine acting on the wild-type protein would expose normal tissue too. HPA KIF23: RNA tissue enhanced (bone marrow 20 nTPM, lymphoid tissue 15 nTPM); blood lineage group enriched (granulocytes 5 nTPM, monocytes 1 nTPM, T-cells 1 nTPM); no normal tissue stained high; highest cancer staining lymphoma (10 of 12 high). Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Hepatocellular carcinoma); Open Targets associates it with 0 specific cancer types at or above 0.5. (Rule 7 of scripts/fetch-target-specificity.ts.)","specificitySources":[{"label":"Human Protein Atlas KIF23 tissue","url":"https://www.proteinatlas.org/ENSG00000137807-KIF23/tissue","note":"RNA tissue and blood lineage specificity, normal tissue antibody staining (version 25.1, CC BY-SA 3.0)"},{"label":"Open Targets ENSG00000137807 associations","url":"https://platform.opentargets.org/target/ENSG00000137807/associations","note":"cancer associations at or above 0.5 (CC0)"}],"hgnc":"HGNC:6392","ensembl":"ENSG00000137807","uniprot":"Q02241","entrez":"9493","firstDescribed":1992,"firstDescribedBasis":"sequence","firstDescribedNote":"Earliest sequence paper UniProt cites for the protein: Nislow et al, Nature, 1992, \"A plus-end-directed motor enzyme that moves antiparallel microtubules in vitro localizes to the interzone of mitotic spindles\".","firstDescribedSource":"https://pubmed.ncbi.nlm.nih.gov/1406973/","biology":"Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signalling required for the myosin contractile ring formation during the cell cycle cytokinesis. Essential for cytokinesis in Rho-mediated signalling. Required for the localisation of ECT2 to the central spindle. Plus-end-directed motor enzyme that moves antiparallel microtubules in vitro. Location: Nucleus; Cytoplasm, cytoskeleton, spindle; Midbody, Midbody ring; Midbody (UniProt). Locus 15q23 (HGNC).","whereFound":["Hepatocellular carcinoma: CIViC evidence names this disease"],"targetClass":"other","prevalence":[]},"route":"/targets/kif23/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"}],"cancer":[{"id":"hcc","kind":"cancer","name":"Hepatocellular carcinoma","route":"/cancers/hcc/"}]}}