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KCNQ3 (Potassium voltage-gated channel subfamily KQT member 3) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it.
Pore-forming subunit of the voltage-gated potassium (Kv) M-channel which is responsible for the M-current, a key controller of neuronal excitability. M-channel is composed of pore-forming subunits KCNQ2 and KCNQ3 assembled as heterotetramers. The native M-current has a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs.
Open Targets scores its association with cancer at 0.56 (direct and indirect evidence; datatypes literature 0.61, genetic association 0.41, somatic mutation 0.23, clinical 0.76).
In plain words · KCNQ3 (Potassium voltage-gated channel subfamily KQT member 3) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it.
KCNQ3 (Potassium voltage-gated channel subfamily KQT member 3) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it.
Pore-forming subunit of the voltage-gated potassium (Kv) M-channel which is responsible for the M-current, a key controller of neuronal excitability.
No product in this corpus aims at KCNQ3 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the role drug-target; HPA finds the RNA tissue enriched, which says where the protein sits but not whether the tumour differs from normal tissue. HPA KCNQ3: RNA tissue enriched (brain 16 nTPM); no normal tissue stained high. Distribution: no corpus cancer carries a prevalence row, threshold or catalogue link for it; Open Targets associates it with 1 specific cancer type at or above 0.5 (Lambert-Eaton myasthenic syndrome). (No rule of scripts/fetch-target-specificity.ts fired.)
Sources: Human Protein Atlas KCNQ3 tissue; Open Targets ENSG00000184156 associations
First described 1998. Earliest sequence paper UniProt cites for the protein: Schroeder B.C. et al, Nature, 1998, "Moderate loss of function of cyclic-AMP-modulated KCNQ2/KCNQ3 K+ channels causes epilepsy". Source.
Sources: HGNC HGNC:6297 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt O43525 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000184156 (association with cancer (MONDO_0004992) 0.56; (GraphQL API, CC0))
Pore-forming subunit of the voltage-gated potassium (Kv) M-channel which is responsible for the M-current, a key controller of neuronal excitability. M-channel is composed of pore-forming subunits KCNQ2 and KCNQ3 assembled as heterotetramers. The native M-current has a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs. M-channel is selectively permeable in vitro to other cations besides potassium, in decreasing order of affinity K(+) > Rb(+) > Cs(+) > Na(+). M-channel association with SLC5A3/SMIT1 alters channel ion selectivity, increasing Na(+) and Cs(+) permeation relative to K(+). Suppressed by activation of M1 muscarinic acetylcholine receptors. Location: Cell membrane (UniProt). Locus 8q24.22 (HGNC).
RNA: tissue enriched (brain 16 nTPM), detected in some normal tissues.
No normal tissue stained high.
RNA cancer enhanced: Lung Adenocarcinoma 5 pTPM, Thyroid Carcinoma 5 pTPM.
No cancer sample stained medium or high.
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"KCNQ3" OR ABSTRACT:"KCNQ3" OR TITLE:"potassium voltage-gated channel subfamily Q member 3" OR ABSTRACT:"potassium voltage-gated channel subfamily Q member 3" OR TITLE:"Potassium voltage-gated channel subfamily KQT member 3" OR ABSTRACT:"Potassium voltage-gated channel subfamily KQT member 3" OR TITLE:"Kv7.3" OR ABSTRACT:"Kv7.3" OR TITLE:"EBN2" OR ABSTRACT:"EBN2") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about KCNQ3, not a curated reading list.