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KCNQ3 (Potassium voltage-gated channel subfamily KQT member 3) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Pore-forming subunit of the voltage-gated potassium (Kv) M-channel which is responsible for the M-current, a key controller of neuronal excitability. M-channel is composed of pore-forming subunits KCNQ2 and KCNQ3 assembled as heterotetramers. The native M-current has a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs. M-channel is selectively permeable in vitro to other cations besides potassium, in decreasing order of affinity K(+) > Rb(+) > Cs(+) > Na(+). M-channel association with SLC5A3/SMIT1 alters channel ion selectivity, increasing Na(+) and Cs(+) permeation relative to K(+). Suppressed by activation of M1 muscarinic acetylcholine receptors. Location: Cell membrane (UniProt). Locus 8q24.22 (HGNC).
No product in the corpus is aimed at this target yet.
No trial in the corpus names this target or one of its products.
No recorded escape route names this target.
No pathway diagram carries this target as a node.
No companion diagnostic in the registry measures this target.
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Query for this target: (TITLE:"KCNQ3" OR ABSTRACT:"KCNQ3" OR TITLE:"potassium voltage-gated channel subfamily Q member 3" OR ABSTRACT:"potassium voltage-gated channel subfamily Q member 3" OR TITLE:"Potassium voltage-gated channel subfamily KQT member 3" OR ABSTRACT:"Potassium voltage-gated channel subfamily KQT member 3" OR TITLE:"Kv7.3" OR ABSTRACT:"Kv7.3" OR TITLE:"EBN2" OR ABSTRACT:"EBN2") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about KCNQ3, not a curated reading list.
The dossier as machine-readable JSON, at /api/v1/dossiers/kcnq3.json: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/kcnq3.json. Licence CC BY-NC 4.0.