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JAZF1 (Juxtaposed with another zinc finger protein 1) is a protein that switches other genes on and off. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Skin cancer and Prostate cancer.
Acts as a transcriptional corepressor of orphan nuclear receptor NR2C2. Inhibits expression of the gluconeogenesis enzyme PCK2 through inhibition of NR2C2 activity. Also involved in transcriptional activation of NAMPT by promoting expression of PPARA and PPARD.
Open Targets scores its association with cancer at 0.60 (direct and indirect evidence; datatypes literature 0.92, genetic association 0.68, somatic mutation 0.49).
In plain words · JAZF1 (Juxtaposed with another zinc finger protein 1) is a protein that switches other genes on and off. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Skin cancer and Prostate cancer.
JAZF1 (Juxtaposed with another zinc finger protein 1) is a protein that switches other genes on and off. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Skin cancer and Prostate cancer.
Acts as a transcriptional corepressor of orphan nuclear receptor NR2C2. Inhibits expression of the gluconeogenesis enzyme PCK2 through inhibition of NR2C2 activity.
No product in this corpus aims at JAZF1 yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
First described 2003. Earliest sequence paper UniProt cites for the protein: Scherer S.W. et al, Science, 2003, "Human chromosome 7: DNA sequence and biology". Source.
Sources: HGNC HGNC:28917 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q86VZ6 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000153814 (association with cancer (MONDO_0004992) 0.60; per-cancer scores at or above 0.5: prostate cancer 0.52, skin cancer 0.55 (GraphQL API, CC0))
Acts as a transcriptional corepressor of orphan nuclear receptor NR2C2. Inhibits expression of the gluconeogenesis enzyme PCK2 through inhibition of NR2C2 activity. Also involved in transcriptional activation of NAMPT by promoting expression of PPARA and PPARD. Plays a role in lipid metabolism by suppressing lipogenesis, increasing lipolysis and decreasing lipid accumulation in adipose tissue. Plays a role in glucose homeostasis by improving glucose metabolism and insulin sensitivity. Location: Nucleus (UniProt). Locus 7p15.2-p15.1 (HGNC).
Query for this target: (TITLE:"JAZF1" OR ABSTRACT:"JAZF1" OR TITLE:"JAZF zinc finger 1" OR ABSTRACT:"JAZF zinc finger 1" OR TITLE:"Juxtaposed with another zinc finger protein 1" OR ABSTRACT:"Juxtaposed with another zinc finger protein 1" OR TITLE:"TIP27" OR ABSTRACT:"TIP27" OR TITLE:"DKFZp761K2222" OR ABSTRACT:"DKFZp761K2222" OR TITLE:"ZNF802" OR ABSTRACT:"ZNF802") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about JAZF1, not a curated reading list.