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JAZF1 (Juxtaposed with another zinc finger protein 1) is a protein that switches other genes on and off. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Skin cancer and Prostate cancer. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Acts as a transcriptional corepressor of orphan nuclear receptor NR2C2. Inhibits expression of the gluconeogenesis enzyme PCK2 through inhibition of NR2C2 activity. Also involved in transcriptional activation of NAMPT by promoting expression of PPARA and PPARD. Plays a role in lipid metabolism by suppressing lipogenesis, increasing lipolysis and decreasing lipid accumulation in adipose tissue. Plays a role in glucose homeostasis by improving glucose metabolism and insulin sensitivity. Location: Nucleus (UniProt). Locus 7p15.2-p15.1 (HGNC).
No product in the corpus is aimed at this target yet.
No trial in the corpus names this target or one of its products.
No recorded escape route names this target.
No pathway diagram carries this target as a node.
No companion diagnostic in the registry measures this target.
No model entry for this target yet; check the cancer entries on the models page.
No open questions recorded for this target yet. Suggest one.
Query for this target: (TITLE:"JAZF1" OR ABSTRACT:"JAZF1" OR TITLE:"JAZF zinc finger 1" OR ABSTRACT:"JAZF zinc finger 1" OR TITLE:"Juxtaposed with another zinc finger protein 1" OR ABSTRACT:"Juxtaposed with another zinc finger protein 1" OR TITLE:"TIP27" OR ABSTRACT:"TIP27" OR TITLE:"DKFZp761K2222" OR ABSTRACT:"DKFZp761K2222" OR TITLE:"ZNF802" OR ABSTRACT:"ZNF802") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about JAZF1, not a curated reading list.
The dossier as machine-readable JSON, at /api/v1/dossiers/jazf1.json: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/jazf1.json. Licence CC BY-NC 4.0.