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ITPKB (Inositol-trisphosphate 3-kinase B) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Diffuse large B-cell lymphoma.
Catalyses the phosphorylation of 1D-myo-inositol 1,4,5-trisphosphate (InsP3) into 1D-myo-inositol 1,3,4,5-tetrakisphosphate and participates to the regulation of calcium homeostasis.
CIViC holds 1 clinical evidence item and 0 assertions across 1 variant.
In plain words · ITPKB (Inositol-trisphosphate 3-kinase B) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Diffuse large B-cell lymphoma.
ITPKB (Inositol-trisphosphate 3-kinase B) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Diffuse large B-cell lymphoma.
Catalyses the phosphorylation of 1D-myo-inositol 1,4,5-trisphosphate (InsP3) into 1D-myo-inositol 1,3,4,5-tetrakisphosphate and participates to the regulation of calcium homeostasis.
No product in this corpus aims at ITPKB yet. Kinases are switched on by binding ATP inside the cell, so most drugs are small molecules shaped to plug that ATP pocket.
Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the role biomarker; HPA finds the RNA tissue enhanced, which says where the protein sits but not whether the tumour differs from normal tissue. HPA ITPKB: RNA tissue enhanced (brain 99 nTPM, choroid plexus 90 nTPM); high antibody staining in 1 normal tissue. Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Lymphoma); Open Targets associates it with 0 specific cancer types at or above 0.5. (No rule of scripts/fetch-target-specificity.ts fired.)
Sources: Human Protein Atlas ITPKB tissue; Open Targets ENSG00000143772 associations
First described 1991. Earliest sequence paper UniProt cites for the protein: Takazawa et al, Biochem. J, 1991, "Molecular cloning and expression of a new putative inositol 1,4,5-trisphosphate 3-kinase isoenzyme". Source.
Sources: HGNC HGNC:6179 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P27987 (protein name, function text, keywords and locations (REST API)); CIViC gene ITPKB (1 evidence items, 0 assertions, 1 variants; diseases: Diffuse Large B-cell Lymphoma (GraphQL API, CC0))
Catalyses the phosphorylation of 1D-myo-inositol 1,4,5-trisphosphate (InsP3) into 1D-myo-inositol 1,3,4,5-tetrakisphosphate and participates to the regulation of calcium homeostasis. Location: Cytoplasm, cytoskeleton; Cytoplasm; Endoplasmic reticulum (UniProt). Locus 1q42.12 (HGNC).
RNA: tissue enhanced (brain 99 nTPM, choroid plexus 90 nTPM), detected in many normal tissues.
Medium: Caudate, Cerebral cortex, Hippocampus, Lung, Smooth muscle.
RNA cancer enhanced: Skin Cutaneous Melanoma 87 pTPM.
No cancer stained high; medium in melanoma.
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"ITPKB" OR ABSTRACT:"ITPKB" OR TITLE:"inositol-trisphosphate 3-kinase B" OR ABSTRACT:"inositol-trisphosphate 3-kinase B" OR TITLE:"Inositol-trisphosphate 3-kinase B" OR ABSTRACT:"Inositol-trisphosphate 3-kinase B" OR TITLE:"IP3KB" OR ABSTRACT:"IP3KB" OR TITLE:"IP3-3KB" OR ABSTRACT:"IP3-3KB") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about ITPKB, not a curated reading list.