{"entity":{"id":"itpkb","kind":"target","name":"ITPKB","aka":["inositol-trisphosphate 3-kinase B","Inositol-trisphosphate 3-kinase B","IP3KB","IP3-3KB"],"tldr":"ITPKB (Inositol-trisphosphate 3-kinase B) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Diffuse large B-cell lymphoma.","summary":"Catalyses the phosphorylation of 1D-myo-inositol 1,4,5-trisphosphate (InsP3) into 1D-myo-inositol 1,3,4,5-tetrakisphosphate and participates to the regulation of calcium homeostasis.\n\nCIViC holds 1 clinical evidence item and 0 assertions across 1 variant.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:6179","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6179"},{"label":"UniProt P27987","url":"https://www.uniprot.org/uniprotkb/P27987/entry"},{"label":"NCBI Gene 3707","url":"https://www.ncbi.nlm.nih.gov/gene/3707"},{"label":"Ensembl ENSG00000143772","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000143772"}],"tags":["cancer-genes-wave"],"related":["civic"],"cancers":["dlbcl"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC holds 1 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"ITPKB","role":["biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:6179","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6179","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P27987","url":"https://www.uniprot.org/uniprotkb/P27987/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene ITPKB","url":"https://civicdb.org/features/3083","note":"1 evidence items, 0 assertions, 1 variants; diseases: Diffuse Large B-cell Lymphoma (GraphQL API, CC0)"}],"distribution":"one-type","specificityNote":"Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the role biomarker; HPA finds the RNA tissue enhanced, which says where the protein sits but not whether the tumour differs from normal tissue. HPA ITPKB: RNA tissue enhanced (brain 99 nTPM, choroid plexus 90 nTPM); high antibody staining in 1 normal tissue. Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Lymphoma); Open Targets associates it with 0 specific cancer types at or above 0.5. (No rule of scripts/fetch-target-specificity.ts fired.)","specificitySources":[{"label":"Human Protein Atlas ITPKB tissue","url":"https://www.proteinatlas.org/ENSG00000143772-ITPKB/tissue","note":"RNA tissue and blood lineage specificity, normal tissue antibody staining (version 25.1, CC BY-SA 3.0)"},{"label":"Open Targets ENSG00000143772 associations","url":"https://platform.opentargets.org/target/ENSG00000143772/associations","note":"cancer associations at or above 0.5 (CC0)"}],"hgnc":"HGNC:6179","ensembl":"ENSG00000143772","uniprot":"P27987","entrez":"3707","firstDescribed":1991,"firstDescribedBasis":"sequence","firstDescribedNote":"Earliest sequence paper UniProt cites for the protein: Takazawa et al, Biochem. J, 1991, \"Molecular cloning and expression of a new putative inositol 1,4,5-trisphosphate 3-kinase isoenzyme\".","firstDescribedSource":"https://pubmed.ncbi.nlm.nih.gov/1654894/","biology":"Catalyses the phosphorylation of 1D-myo-inositol 1,4,5-trisphosphate (InsP3) into 1D-myo-inositol 1,3,4,5-tetrakisphosphate and participates to the regulation of calcium homeostasis. Location: Cytoplasm, cytoskeleton; Cytoplasm; Endoplasmic reticulum (UniProt). Locus 1q42.12 (HGNC).","whereFound":["Diffuse large B-cell lymphoma: CIViC evidence names this disease"],"targetClass":"kinase","prevalence":[]},"route":"/targets/itpkb/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"}],"cancer":[{"id":"dlbcl","kind":"cancer","name":"Diffuse large B-cell lymphoma","route":"/cancers/dlbcl/"}]}}