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ITGA6 (Integrin alpha-6) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Prostate cancer.
Integrin alpha-6/beta-1 (ITGA6:ITGB1) is a receptor for laminin on platelets. Integrin alpha-6/beta-1 (ITGA6:ITGB1) is present in oocytes and is involved in sperm-egg fusion. Integrin alpha-6/beta-4 (ITGA6:ITGB4) is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome.
Open Targets scores its association with cancer at 0.54 (direct and indirect evidence; datatypes literature 0.98, genetic association 0.67).
In plain words · ITGA6 (Integrin alpha-6) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Prostate cancer.
ITGA6 (Integrin alpha-6) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Prostate cancer.
Integrin alpha-6/beta-1 (ITGA6:ITGB1) is a receptor for laminin on platelets. Integrin alpha-6/beta-1 (ITGA6:ITGB1) is present in oocytes and is involved in sperm-egg fusion.
No product in this corpus aims at ITGA6 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 1989. Earliest sequence paper UniProt cites for the protein: Hemler M.E. et al, J. Biol. Chem, 1989, "Association of the VLA alpha 6 subunit with a novel protein. A possible alternative to the common VLA beta 1 subunit on certain cell lines". Source.
Sources: HGNC HGNC:6142 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P23229 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000091409 (association with cancer (MONDO_0004992) 0.54; per-cancer scores at or above 0.5: prostate cancer 0.51 (GraphQL API, CC0))
Integrin alpha-6/beta-1 (ITGA6:ITGB1) is a receptor for laminin on platelets. Integrin alpha-6/beta-1 (ITGA6:ITGB1) is present in oocytes and is involved in sperm-egg fusion. Integrin alpha-6/beta-4 (ITGA6:ITGB4) is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signalling. ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signalling. ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signalling. Location: Cell membrane (UniProt). Locus 2q31.1 (HGNC).
Query for this target: (TITLE:"ITGA6" OR ABSTRACT:"ITGA6" OR TITLE:"integrin subunit alpha 6" OR ABSTRACT:"integrin subunit alpha 6" OR TITLE:"Integrin alpha-6" OR ABSTRACT:"Integrin alpha-6" OR TITLE:"CD49f" OR ABSTRACT:"CD49f" OR TITLE:"VLA-6" OR ABSTRACT:"VLA-6" OR TITLE:"ITGA6A" OR ABSTRACT:"ITGA6A") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about ITGA6, not a curated reading list.