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ITGA6 (Integrin alpha-6) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Prostate cancer. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Integrin alpha-6/beta-1 (ITGA6:ITGB1) is a receptor for laminin on platelets. Integrin alpha-6/beta-1 (ITGA6:ITGB1) is present in oocytes and is involved in sperm-egg fusion. Integrin alpha-6/beta-4 (ITGA6:ITGB4) is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signalling. ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signalling. ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signalling. Location: Cell membrane (UniProt). Locus 2q31.1 (HGNC).
No product in the corpus is aimed at this target yet.
No trial in the corpus names this target or one of its products.
No recorded escape route names this target.
No pathway diagram carries this target as a node.
No companion diagnostic in the registry measures this target.
No model entry for this target yet; check the cancer entries on the models page.
No open questions recorded for this target yet. Suggest one.
Query for this target: (TITLE:"ITGA6" OR ABSTRACT:"ITGA6" OR TITLE:"integrin subunit alpha 6" OR ABSTRACT:"integrin subunit alpha 6" OR TITLE:"Integrin alpha-6" OR ABSTRACT:"Integrin alpha-6" OR TITLE:"CD49f" OR ABSTRACT:"CD49f" OR TITLE:"VLA-6" OR ABSTRACT:"VLA-6" OR TITLE:"ITGA6A" OR ABSTRACT:"ITGA6A") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about ITGA6, not a curated reading list.
The dossier as machine-readable JSON, at /api/v1/dossiers/itga6.json: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/itga6.json. Licence CC BY-NC 4.0.