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IL4R (Interleukin-4 receptor subunit alpha) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Diffuse large B-cell lymphoma.
Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation.
CIViC holds 1 clinical evidence item and 0 assertions across 1 variant.
In plain words · IL4R (Interleukin-4 receptor subunit alpha) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Diffuse large B-cell lymphoma.
IL4R (Interleukin-4 receptor subunit alpha) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Diffuse large B-cell lymphoma.
Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway.
No product in this corpus aims at IL4R yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
Broadly expressed or essential: HPA finds the RNA at low tissue specificity; a medicine acting on the wild-type protein would expose normal tissue too. HPA IL4R: RNA low tissue specificity; blood lineage group enriched (B-cells 77 nTPM, granulocytes 31 nTPM); no normal tissue stained high; highest cancer staining glioma (1 of 9 high). Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Lymphoma); Open Targets associates it with 0 specific cancer types at or above 0.5. (Rule 7 of scripts/fetch-target-specificity.ts.)
Sources: Human Protein Atlas IL4R tissue; Open Targets ENSG00000077238 associations
First described 1990. Earliest sequence paper UniProt cites for the protein: Idzerda R.L. et al, J. Exp. Med, 1990, "Human interleukin 4 receptor confers biological responsiveness and defines a novel receptor superfamily". Source.
Sources: HGNC HGNC:6015 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P24394 (protein name, function text, keywords and locations (REST API)); CIViC gene IL4R (1 evidence items, 0 assertions, 1 variants; diseases: Diffuse Large B-cell Lymphoma (GraphQL API, CC0))
Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2. Soluble IL4R (sIL4R) inhibits IL4-mediated cell proliferation and IL5 up-regulation by T-cells. Location: Cell membrane; Secreted (UniProt). Locus 16p12.1 (HGNC).
RNA: low tissue specificity, detected in all normal tissues. Blood: group enriched (B-cells 77 nTPM, granulocytes 31 nTPM).
No normal tissue stained high; medium in Appendix, Bone marrow, Breast, Colon, Duodenum, Lymph node and more.
Medium only: breast cancer, cervical cancer, colorectal cancer, endometrial cancer.
HPA IL4R tissue · HPA IL4R pathology · HPA protein class: CD markers, FDA approved drug targets
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"IL4R" OR ABSTRACT:"IL4R" OR TITLE:"interleukin 4 receptor" OR ABSTRACT:"interleukin 4 receptor" OR TITLE:"Interleukin-4 receptor subunit alpha" OR ABSTRACT:"Interleukin-4 receptor subunit alpha" OR TITLE:"CD124" OR ABSTRACT:"CD124") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about IL4R, not a curated reading list.