{"entity":{"id":"il4r","kind":"target","name":"IL4R","aka":["interleukin 4 receptor","Interleukin-4 receptor subunit alpha","CD124"],"tldr":"IL4R (Interleukin-4 receptor subunit alpha) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Diffuse large B-cell lymphoma.","summary":"Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation.\n\nCIViC holds 1 clinical evidence item and 0 assertions across 1 variant.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:6015","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6015"},{"label":"UniProt P24394","url":"https://www.uniprot.org/uniprotkb/P24394/entry"},{"label":"NCBI Gene 3566","url":"https://www.ncbi.nlm.nih.gov/gene/3566"},{"label":"Ensembl ENSG00000077238","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000077238"}],"tags":["cancer-genes-wave"],"related":["civic"],"cancers":["dlbcl"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC holds 1 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"IL4R","role":["biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:6015","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6015","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P24394","url":"https://www.uniprot.org/uniprotkb/P24394/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene IL4R","url":"https://civicdb.org/features/2967","note":"1 evidence items, 0 assertions, 1 variants; diseases: Diffuse Large B-cell Lymphoma (GraphQL API, CC0)"}],"specificity":"broadly-expressed","distribution":"one-type","specificityNote":"Broadly expressed or essential: HPA finds the RNA at low tissue specificity; a medicine acting on the wild-type protein would expose normal tissue too. HPA IL4R: RNA low tissue specificity; blood lineage group enriched (B-cells 77 nTPM, granulocytes 31 nTPM); no normal tissue stained high; highest cancer staining glioma (1 of 9 high). Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Lymphoma); Open Targets associates it with 0 specific cancer types at or above 0.5. (Rule 7 of scripts/fetch-target-specificity.ts.)","specificitySources":[{"label":"Human Protein Atlas IL4R tissue","url":"https://www.proteinatlas.org/ENSG00000077238-IL4R/tissue","note":"RNA tissue and blood lineage specificity, normal tissue antibody staining (version 25.1, CC BY-SA 3.0)"},{"label":"Open Targets ENSG00000077238 associations","url":"https://platform.opentargets.org/target/ENSG00000077238/associations","note":"cancer associations at or above 0.5 (CC0)"}],"hgnc":"HGNC:6015","ensembl":"ENSG00000077238","uniprot":"P24394","entrez":"3566","firstDescribed":1990,"firstDescribedBasis":"sequence","firstDescribedNote":"Earliest sequence paper UniProt cites for the protein: Idzerda R.L. et al, J. Exp. Med, 1990, \"Human interleukin 4 receptor confers biological responsiveness and defines a novel receptor superfamily\".","firstDescribedSource":"https://pubmed.ncbi.nlm.nih.gov/2307934/","biology":"Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2. Soluble IL4R (sIL4R) inhibits IL4-mediated cell proliferation and IL5 up-regulation by T-cells. Location: Cell membrane; Secreted (UniProt). Locus 16p12.1 (HGNC).","whereFound":["Diffuse large B-cell lymphoma: CIViC evidence names this disease"],"targetClass":"other","prevalence":[]},"route":"/targets/il4r/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"}],"cancer":[{"id":"dlbcl","kind":"cancer","name":"Diffuse large B-cell lymphoma","route":"/cancers/dlbcl/"}]}}