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IFNA2 (Interferon alpha-2) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it.
Produced by macrophages, IFN-alpha have antiviral activities.
Open Targets scores its association with cancer at 0.52 (direct and indirect evidence; datatypes literature 0.96, clinical 0.81).
In plain words · IFNA2 (Interferon alpha-2) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it.
IFNA2 (Interferon alpha-2) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it.
Produced by macrophages, IFN-alpha have antiviral activities. Location: Secreted (UniProt).
No product in this corpus aims at IFNA2 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the role drug-target; HPA finds the RNA not detected, which says where the protein sits but not whether the tumour differs from normal tissue. HPA IFNA2: RNA not detected; no normal tissue stained high. Distribution: no corpus cancer carries a prevalence row, threshold or catalogue link for it; Open Targets associates it with 0 specific cancer types at or above 0.5. (No rule of scripts/fetch-target-specificity.ts fired.)
Sources: Human Protein Atlas IFNA2 tissue; Open Targets ENSG00000188379 associations
First described 1980. Earliest sequence paper UniProt cites for the protein: Goeddel D.V. et al, Nature, 1980, "Human leukocyte interferon produced by E. coli is biologically active". Source.
Sources: HGNC HGNC:5423 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P01563 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000188379 (association with cancer (MONDO_0004992) 0.52; (GraphQL API, CC0))
Produced by macrophages, IFN-alpha have antiviral activities. Location: Secreted (UniProt). Locus 9p21.3 (HGNC).
RNA: not detected, not detected normal tissues.
No normal tissue stained high.
No cancer stained high; medium in glioma, stomach cancer.
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"IFNA2" OR ABSTRACT:"IFNA2" OR TITLE:"interferon alpha 2" OR ABSTRACT:"interferon alpha 2" OR TITLE:"Interferon alpha-2" OR ABSTRACT:"Interferon alpha-2" OR TITLE:"IFN-alphaA" OR ABSTRACT:"IFN-alphaA") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about IFNA2, not a curated reading list.