{"entity":{"id":"ifna2","kind":"target","name":"IFNA2","aka":["interferon alpha 2","Interferon alpha-2","IFN-alphaA"],"tldr":"IFNA2 (Interferon alpha-2) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it.","summary":"Produced by macrophages, IFN-alpha have antiviral activities.\n\nOpen Targets scores its association with cancer at 0.52 (direct and indirect evidence; datatypes literature 0.96, clinical 0.81).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:5423","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:5423"},{"label":"UniProt P01563","url":"https://www.uniprot.org/uniprotkb/P01563/entry"},{"label":"NCBI Gene 3440","url":"https://www.ncbi.nlm.nih.gov/gene/3440"},{"label":"Ensembl ENSG00000188379","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000188379"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.81. Evidence tier \"approved-drug\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"IFNA2","role":["drug-target"],"evidenceTier":"approved-drug","sources":[{"label":"HGNC HGNC:5423","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:5423","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P01563","url":"https://www.uniprot.org/uniprotkb/P01563/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000188379","url":"https://platform.opentargets.org/target/ENSG00000188379/associations","note":"association with cancer (MONDO_0004992) 0.52;  (GraphQL API, CC0)"}],"distribution":"not-established","specificityNote":"Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the role drug-target; HPA finds the RNA not detected, which says where the protein sits but not whether the tumour differs from normal tissue. HPA IFNA2: RNA not detected; no normal tissue stained high. Distribution: no corpus cancer carries a prevalence row, threshold or catalogue link for it; Open Targets associates it with 0 specific cancer types at or above 0.5. (No rule of scripts/fetch-target-specificity.ts fired.)","specificitySources":[{"label":"Human Protein Atlas IFNA2 tissue","url":"https://www.proteinatlas.org/ENSG00000188379-IFNA2/tissue","note":"RNA tissue and blood lineage specificity, normal tissue antibody staining (version 25.1, CC BY-SA 3.0)"},{"label":"Open Targets ENSG00000188379 associations","url":"https://platform.opentargets.org/target/ENSG00000188379/associations","note":"cancer associations at or above 0.5 (CC0)"}],"hgnc":"HGNC:5423","ensembl":"ENSG00000188379","uniprot":"P01563","entrez":"3440","firstDescribed":1980,"firstDescribedBasis":"sequence","firstDescribedNote":"Earliest sequence paper UniProt cites for the protein: Goeddel D.V. et al, Nature, 1980, \"Human leukocyte interferon produced by E. coli is biologically active\".","firstDescribedSource":"https://pubmed.ncbi.nlm.nih.gov/6159538/","biology":"Produced by macrophages, IFN-alpha have antiviral activities. Location: Secreted (UniProt). Locus 9p21.3 (HGNC).","whereFound":[],"targetClass":"other","prevalence":[]},"route":"/targets/ifna2/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}]}}