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HSPH1 (Heat shock protein 105 kDa) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Gastric & gastro-oesophageal junction cancer and Colorectal cancer.
Acts as a nucleotide-exchange factor (NEF) for chaperone proteins HSPA1A and HSPA1B, promoting the release of ADP from HSPA1A/B thereby triggering client/substrate protein release. Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. Inhibits HSPA8/HSC70 ATPase and chaperone activities.
CIViC holds 3 clinical evidence items and 0 assertions across 2 variants, naming Fluorouracil, Oxaliplatin and Cisplatin.
In plain words · HSPH1 (Heat shock protein 105 kDa) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Gastric & gastro-oesophageal junction cancer and Colorectal cancer.
HSPH1 (Heat shock protein 105 kDa) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Gastric & gastro-oesophageal junction cancer and Colorectal cancer.
Acts as a nucleotide-exchange factor (NEF) for chaperone proteins HSPA1A and HSPA1B, promoting the release of ADP from HSPA1A/B thereby triggering client/substrate protein release.
No product in this corpus aims at HSPH1 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
Broadly expressed or essential: HPA finds the RNA at low tissue specificity; a medicine acting on the wild-type protein would expose normal tissue too. HPA HSPH1: RNA low tissue specificity; no normal tissue stained high; highest cancer staining urothelial cancer (12 of 12 high). Distribution: 2 cancer families in the corpus carry a prevalence row, label threshold or catalogue link for it (Gastric & gastro-oesophageal junction cancer, Colorectal cancer); Open Targets associates it with 0 specific cancer types at or above 0.5. (Rule 7 of scripts/fetch-target-specificity.ts.)
Sources: Human Protein Atlas HSPH1 tissue; Open Targets ENSG00000120694 associations
First described 1996. Earliest sequence paper UniProt cites for the protein: Nagase et al, DNA Res, 1996, "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain". Source.
Sources: HGNC HGNC:16969 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q92598 (protein name, function text, keywords and locations (REST API)); CIViC gene HSPH1 (3 evidence items, 0 assertions, 2 variants; diseases: Gastric Adenocarcinoma, Colorectal Cancer (GraphQL API, CC0))
Acts as a nucleotide-exchange factor (NEF) for chaperone proteins HSPA1A and HSPA1B, promoting the release of ADP from HSPA1A/B thereby triggering client/substrate protein release. Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. Inhibits HSPA8/HSC70 ATPase and chaperone activities. Location: Cytoplasm (UniProt). Locus 13q12.3 (HGNC).
RNA: low tissue specificity, detected in all normal tissues.
No normal tissue stained high.
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"HSPH1" OR ABSTRACT:"HSPH1" OR TITLE:"heat shock protein family H Hsp110 member 1" OR ABSTRACT:"heat shock protein family H Hsp110 member 1" OR TITLE:"Heat shock protein 105 kDa" OR ABSTRACT:"Heat shock protein 105 kDa" OR TITLE:"HSP105B" OR ABSTRACT:"HSP105B" OR TITLE:"KIAA0201" OR ABSTRACT:"KIAA0201" OR TITLE:"HSP105A" OR ABSTRACT:"HSP105A") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about HSPH1, not a curated reading list.