{"entity":{"id":"hsph1","kind":"target","name":"HSPH1","aka":["heat shock protein family H (Hsp110) member 1","Heat shock protein 105 kDa","HSP105B","KIAA0201","HSP105A","NY-CO-25"],"tldr":"HSPH1 (Heat shock protein 105 kDa) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Gastric & gastro-oesophageal junction cancer and Colorectal cancer.","summary":"Acts as a nucleotide-exchange factor (NEF) for chaperone proteins HSPA1A and HSPA1B, promoting the release of ADP from HSPA1A/B thereby triggering client/substrate protein release. Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. Inhibits HSPA8/HSC70 ATPase and chaperone activities.\n\nCIViC holds 3 clinical evidence items and 0 assertions across 2 variants, naming Fluorouracil, Oxaliplatin and Cisplatin.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:16969","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:16969"},{"label":"UniProt Q92598","url":"https://www.uniprot.org/uniprotkb/Q92598/entry"},{"label":"NCBI Gene 10808","url":"https://www.ncbi.nlm.nih.gov/gene/10808"},{"label":"Ensembl ENSG00000120694","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000120694"}],"tags":["cancer-genes-wave"],"related":["civic"],"cancers":["gastric","colorectal"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 3 therapies; CIViC holds 3 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"HSPH1","role":["drug-target","biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:16969","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:16969","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q92598","url":"https://www.uniprot.org/uniprotkb/Q92598/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene HSPH1","url":"https://civicdb.org/features/8614","note":"3 evidence items, 0 assertions, 2 variants; diseases: Gastric Adenocarcinoma, Colorectal Cancer (GraphQL API, CC0)"}],"specificity":"broadly-expressed","distribution":"few-types","specificityNote":"Broadly expressed or essential: HPA finds the RNA at low tissue specificity; a medicine acting on the wild-type protein would expose normal tissue too. HPA HSPH1: RNA low tissue specificity; no normal tissue stained high; highest cancer staining urothelial cancer (12 of 12 high). Distribution: 2 cancer families in the corpus carry a prevalence row, label threshold or catalogue link for it (Gastric & gastro-oesophageal junction cancer, Colorectal cancer); Open Targets associates it with 0 specific cancer types at or above 0.5. (Rule 7 of scripts/fetch-target-specificity.ts.)","specificitySources":[{"label":"Human Protein Atlas HSPH1 tissue","url":"https://www.proteinatlas.org/ENSG00000120694-HSPH1/tissue","note":"RNA tissue and blood lineage specificity, normal tissue antibody staining (version 25.1, CC BY-SA 3.0)"},{"label":"Open Targets ENSG00000120694 associations","url":"https://platform.opentargets.org/target/ENSG00000120694/associations","note":"cancer associations at or above 0.5 (CC0)"}],"hgnc":"HGNC:16969","ensembl":"ENSG00000120694","uniprot":"Q92598","entrez":"10808","firstDescribed":1996,"firstDescribedBasis":"sequence","firstDescribedNote":"Earliest sequence paper UniProt cites for the protein: Nagase et al, DNA Res, 1996, \"Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain\".","firstDescribedSource":"https://pubmed.ncbi.nlm.nih.gov/9039502/","biology":"Acts as a nucleotide-exchange factor (NEF) for chaperone proteins HSPA1A and HSPA1B, promoting the release of ADP from HSPA1A/B thereby triggering client/substrate protein release. Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. Inhibits HSPA8/HSC70 ATPase and chaperone activities. Location: Cytoplasm (UniProt). Locus 13q12.3 (HGNC).","whereFound":["Gastric & gastro-oesophageal junction cancer: CIViC evidence names this disease","Colorectal cancer: CIViC evidence names this disease"],"targetClass":"other","prevalence":[]},"route":"/targets/hsph1/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"}],"cancer":[{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"},{"id":"gastric","kind":"cancer","name":"Gastric & gastro-oesophageal junction cancer","route":"/cancers/gastric/"}]}}