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HOXD8 (Homeobox protein Hox-D8) is a protein that switches other genes on and off. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Melanoma.
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
CIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Vemurafenib and Dabrafenib.
In plain words · HOXD8 (Homeobox protein Hox-D8) is a protein that switches other genes on and off. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Melanoma.
HOXD8 (Homeobox protein Hox-D8) is a protein that switches other genes on and off. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Melanoma.
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Location: Nucleus (UniProt).
No product in this corpus aims at HOXD8 yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the roles drug-target, biomarker; HPA finds the RNA tissue enhanced, which says where the protein sits but not whether the tumour differs from normal tissue. HPA HOXD8: RNA tissue enhanced (epididymis 94 nTPM, kidney 71 nTPM); no normal tissue stained high. Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Skin cancer (all types)); Open Targets associates it with 0 specific cancer types at or above 0.5. (No rule of scripts/fetch-target-specificity.ts fired.)
Sources: Human Protein Atlas HOXD8 tissue; Open Targets ENSG00000175879 associations
First described 1989. Earliest sequence paper UniProt cites for the protein: Oliver et al, Genes Dev, 1989, "Complementary homeo protein gradients in developing limb buds". Source.
Sources: HGNC HGNC:5139 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P13378 (protein name, function text, keywords and locations (REST API)); CIViC gene HOXD8 (1 evidence items, 0 assertions, 1 variants; diseases: Melanoma (GraphQL API, CC0))
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Location: Nucleus (UniProt). Locus 2q31.1 (HGNC).
RNA: tissue enhanced (epididymis 94 nTPM, kidney 71 nTPM), detected in many normal tissues.
No normal tissue stained high.
RNA cancer enhanced: Kidney Chromophobe 40 pTPM.
No cancer sample stained medium or high.
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"HOXD8" OR ABSTRACT:"HOXD8" OR TITLE:"homeobox D8" OR ABSTRACT:"homeobox D8" OR TITLE:"Homeobox protein Hox-D8" OR ABSTRACT:"Homeobox protein Hox-D8" OR TITLE:"HOX4" OR ABSTRACT:"HOX4" OR TITLE:"HOX4E" OR ABSTRACT:"HOX4E") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about HOXD8, not a curated reading list.