{"entity":{"id":"hoxd8","kind":"target","name":"HOXD8","aka":["homeobox D8","Homeobox protein Hox-D8","HOX4","HOX4E"],"tldr":"HOXD8 (Homeobox protein Hox-D8) is a protein that switches other genes on and off. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Melanoma.","summary":"Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.\n\nCIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Vemurafenib and Dabrafenib.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:5139","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:5139"},{"label":"UniProt P13378","url":"https://www.uniprot.org/uniprotkb/P13378/entry"},{"label":"NCBI Gene 3234","url":"https://www.ncbi.nlm.nih.gov/gene/3234"},{"label":"Ensembl ENSG00000175879","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000175879"}],"tags":["cancer-genes-wave"],"related":["civic"],"cancers":["melanoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 2 therapies; CIViC holds 1 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"HOXD8","role":["drug-target","biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:5139","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:5139","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P13378","url":"https://www.uniprot.org/uniprotkb/P13378/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene HOXD8","url":"https://civicdb.org/features/2723","note":"1 evidence items, 0 assertions, 1 variants; diseases: Melanoma (GraphQL API, CC0)"}],"distribution":"one-type","specificityNote":"Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the roles drug-target, biomarker; HPA finds the RNA tissue enhanced, which says where the protein sits but not whether the tumour differs from normal tissue. HPA HOXD8: RNA tissue enhanced (epididymis 94 nTPM, kidney 71 nTPM); no normal tissue stained high. Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Skin cancer (all types)); Open Targets associates it with 0 specific cancer types at or above 0.5. (No rule of scripts/fetch-target-specificity.ts fired.)","specificitySources":[{"label":"Human Protein Atlas HOXD8 tissue","url":"https://www.proteinatlas.org/ENSG00000175879-HOXD8/tissue","note":"RNA tissue and blood lineage specificity, normal tissue antibody staining (version 25.1, CC BY-SA 3.0)"},{"label":"Open Targets ENSG00000175879 associations","url":"https://platform.opentargets.org/target/ENSG00000175879/associations","note":"cancer associations at or above 0.5 (CC0)"}],"hgnc":"HGNC:5139","ensembl":"ENSG00000175879","uniprot":"P13378","entrez":"3234","firstDescribed":1989,"firstDescribedBasis":"sequence","firstDescribedNote":"Earliest sequence paper UniProt cites for the protein: Oliver et al, Genes Dev, 1989, \"Complementary homeo protein gradients in developing limb buds\".","firstDescribedSource":"https://pubmed.ncbi.nlm.nih.gov/2568311/","biology":"Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Location: Nucleus (UniProt). Locus 2q31.1 (HGNC).","whereFound":["Melanoma: CIViC evidence names this disease"],"targetClass":"transcription","prevalence":[]},"route":"/targets/hoxd8/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"}],"cancer":[{"id":"melanoma","kind":"cancer","name":"Melanoma","route":"/cancers/melanoma/"}]}}