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HOXC10 (Homeobox protein Hox-C10) is a protein that switches other genes on and off. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response.
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
CIViC holds 2 clinical evidence items and 0 assertions across 1 variant, naming Bevacizumab.
In plain words · HOXC10 (Homeobox protein Hox-C10) is a protein that switches other genes on and off. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response.
HOXC10 (Homeobox protein Hox-C10) is a protein that switches other genes on and off. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response.
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Location: Nucleus (UniProt).
No product in this corpus aims at HOXC10 yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the roles drug-target, biomarker; HPA finds the RNA tissue enhanced, which says where the protein sits but not whether the tumour differs from normal tissue. HPA HOXC10: RNA tissue enhanced (blood vessel 23 nTPM, kidney 28 nTPM, skeletal muscle 106 nTPM); no normal tissue stained high; highest cancer staining carcinoid (2 of 4 high). Distribution: no corpus cancer carries a prevalence row, threshold or catalogue link for it; Open Targets associates it with 0 specific cancer types at or above 0.5. (No rule of scripts/fetch-target-specificity.ts fired.)
Sources: Human Protein Atlas HOXC10 tissue; Open Targets ENSG00000180818 associations
First described 1997. Earliest sequence paper UniProt cites for the protein: Flagiello et al, FEBS Lett, 1997, "Distinct patterns of all-trans retinoic acid dependent expression of HOXB and HOXC homeogenes in human embryonal and small-cell lung carcinoma cell lines". Source.
Sources: HGNC HGNC:5122 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9NYD6 (protein name, function text, keywords and locations (REST API)); CIViC gene HOXC10 (2 evidence items, 0 assertions, 1 variants; diseases: Glioma (GraphQL API, CC0))
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Location: Nucleus (UniProt). Locus 12q13.13 (HGNC).
RNA: tissue enhanced (blood vessel 23 nTPM, kidney 28 nTPM, skeletal muscle 106 nTPM), detected in many normal tissues.
No normal tissue stained high.
Medium only: breast cancer, colorectal cancer, endometrial cancer, head and neck cancer.
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"HOXC10" OR ABSTRACT:"HOXC10" OR TITLE:"homeobox C10" OR ABSTRACT:"homeobox C10" OR TITLE:"Homeobox protein Hox-C10" OR ABSTRACT:"Homeobox protein Hox-C10" OR TITLE:"HOX3I" OR ABSTRACT:"HOX3I") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about HOXC10, not a curated reading list.