{"entity":{"id":"hoxc10","kind":"target","name":"HOXC10","aka":["homeobox C10","Homeobox protein Hox-C10","HOX3I"],"tldr":"HOXC10 (Homeobox protein Hox-C10) is a protein that switches other genes on and off. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response.","summary":"Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.\n\nCIViC holds 2 clinical evidence items and 0 assertions across 1 variant, naming Bevacizumab.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:5122","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:5122"},{"label":"UniProt Q9NYD6","url":"https://www.uniprot.org/uniprotkb/Q9NYD6/entry"},{"label":"NCBI Gene 3226","url":"https://www.ncbi.nlm.nih.gov/gene/3226"},{"label":"Ensembl ENSG00000180818","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000180818"}],"tags":["cancer-genes-wave"],"related":["civic"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 1 therapies; CIViC holds 2 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate.","Diseases the sources name that have no OnCo cancer page yet, so they are not linked: Glioma."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"HOXC10","role":["drug-target","biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:5122","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:5122","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q9NYD6","url":"https://www.uniprot.org/uniprotkb/Q9NYD6/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene HOXC10","url":"https://civicdb.org/features/2715","note":"2 evidence items, 0 assertions, 1 variants; diseases: Glioma (GraphQL API, CC0)"}],"distribution":"not-established","specificityNote":"Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the roles drug-target, biomarker; HPA finds the RNA tissue enhanced, which says where the protein sits but not whether the tumour differs from normal tissue. HPA HOXC10: RNA tissue enhanced (blood vessel 23 nTPM, kidney 28 nTPM, skeletal muscle 106 nTPM); no normal tissue stained high; highest cancer staining carcinoid (2 of 4 high). Distribution: no corpus cancer carries a prevalence row, threshold or catalogue link for it; Open Targets associates it with 0 specific cancer types at or above 0.5. (No rule of scripts/fetch-target-specificity.ts fired.)","specificitySources":[{"label":"Human Protein Atlas HOXC10 tissue","url":"https://www.proteinatlas.org/ENSG00000180818-HOXC10/tissue","note":"RNA tissue and blood lineage specificity, normal tissue antibody staining (version 25.1, CC BY-SA 3.0)"},{"label":"Open Targets ENSG00000180818 associations","url":"https://platform.opentargets.org/target/ENSG00000180818/associations","note":"cancer associations at or above 0.5 (CC0)"}],"hgnc":"HGNC:5122","ensembl":"ENSG00000180818","uniprot":"Q9NYD6","entrez":"3226","firstDescribed":1997,"firstDescribedBasis":"sequence","firstDescribedNote":"Earliest sequence paper UniProt cites for the protein: Flagiello et al, FEBS Lett, 1997, \"Distinct patterns of all-trans retinoic acid dependent expression of HOXB and HOXC homeogenes in human embryonal and small-cell lung carcinoma cell lines\".","firstDescribedSource":"https://pubmed.ncbi.nlm.nih.gov/9357979/","biology":"Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Location: Nucleus (UniProt). Locus 12q13.13 (HGNC).","whereFound":[],"targetClass":"transcription","prevalence":[]},"route":"/targets/hoxc10/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"}]}}