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HNRNPH1 (Heterogeneous nuclear ribonucleoprotein H) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Mantle cell lymphoma.
This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Mediates pre-mRNA alternative splicing regulation. Inhibits, together with CUGBP1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast.
CIViC holds 2 clinical evidence items and 0 assertions across 1 variant.
In plain words · HNRNPH1 (Heterogeneous nuclear ribonucleoprotein H) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Mantle cell lymphoma.
HNRNPH1 (Heterogeneous nuclear ribonucleoprotein H) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Mantle cell lymphoma.
This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm.
No product in this corpus aims at HNRNPH1 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
Broadly expressed or essential: HPA lists HNRNPH1 among essential proteins and finds the RNA at low tissue specificity; a medicine acting on the wild-type protein would expose normal tissue too. HPA HNRNPH1: RNA low tissue specificity; high antibody staining in 33 normal tissues; highest cancer staining carcinoid (4 of 4 high). Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Lymphoma); Open Targets associates it with 0 specific cancer types at or above 0.5. (Rule 7 of scripts/fetch-target-specificity.ts.)
Sources: Human Protein Atlas HNRNPH1 tissue; Open Targets ENSG00000169045 associations
First described 1992. Earliest sequence paper UniProt cites for the protein: Rasmussen H.H. et al, Electrophoresis, 1992, "Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes". Source.
Sources: HGNC HGNC:5041 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P31943 (protein name, function text, keywords and locations (REST API)); CIViC gene HNRNPH1 (2 evidence items, 0 assertions, 1 variants; diseases: Mantle Cell Lymphoma (GraphQL API, CC0))
This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Mediates pre-mRNA alternative splicing regulation. Inhibits, together with CUGBP1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Binds to the IR RNA. Binds poly(RG). Location: Nucleus, nucleoplasm (UniProt). Locus 5q35.3 (HGNC).
RNA: low tissue specificity, detected in all normal tissues.
Medium: Adipose tissue, Esophagus, Fallopian tube, Heart muscle, Liver, Lung, Lymph node, Ovary.
Medium only: cervical cancer, endometrial cancer, head and neck cancer, liver cancer.
HPA HNRNPH1 tissue · HPA HNRNPH1 pathology · HPA protein class: Essential proteins
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"HNRNPH1" OR ABSTRACT:"HNRNPH1" OR TITLE:"heterogeneous nuclear ribonucleoprotein H1" OR ABSTRACT:"heterogeneous nuclear ribonucleoprotein H1" OR TITLE:"Heterogeneous nuclear ribonucleoprotein H" OR ABSTRACT:"Heterogeneous nuclear ribonucleoprotein H" OR TITLE:"hnRNPH" OR ABSTRACT:"hnRNPH" OR TITLE:"HNRPH1" OR ABSTRACT:"HNRPH1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about HNRNPH1, not a curated reading list.