{"entity":{"id":"hnrnph1","kind":"target","name":"HNRNPH1","aka":["heterogeneous nuclear ribonucleoprotein H1","Heterogeneous nuclear ribonucleoprotein H","hnRNPH","HNRPH1"],"tldr":"HNRNPH1 (Heterogeneous nuclear ribonucleoprotein H) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Mantle cell lymphoma.","summary":"This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Mediates pre-mRNA alternative splicing regulation. Inhibits, together with CUGBP1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast.\n\nCIViC holds 2 clinical evidence items and 0 assertions across 1 variant.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:5041","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:5041"},{"label":"UniProt P31943","url":"https://www.uniprot.org/uniprotkb/P31943/entry"},{"label":"NCBI Gene 3187","url":"https://www.ncbi.nlm.nih.gov/gene/3187"},{"label":"Ensembl ENSG00000169045","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000169045"}],"tags":["cancer-genes-wave"],"related":["civic"],"cancers":["mantle-cell-lymphoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC holds 2 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"HNRNPH1","role":["biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:5041","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:5041","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P31943","url":"https://www.uniprot.org/uniprotkb/P31943/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene HNRNPH1","url":"https://civicdb.org/features/2677","note":"2 evidence items, 0 assertions, 1 variants; diseases: Mantle Cell Lymphoma (GraphQL API, CC0)"}],"specificity":"broadly-expressed","distribution":"one-type","specificityNote":"Broadly expressed or essential: HPA lists HNRNPH1 among essential proteins and finds the RNA at low tissue specificity; a medicine acting on the wild-type protein would expose normal tissue too. HPA HNRNPH1: RNA low tissue specificity; high antibody staining in 33 normal tissues; highest cancer staining carcinoid (4 of 4 high). Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Lymphoma); Open Targets associates it with 0 specific cancer types at or above 0.5. (Rule 7 of scripts/fetch-target-specificity.ts.)","specificitySources":[{"label":"Human Protein Atlas HNRNPH1 tissue","url":"https://www.proteinatlas.org/ENSG00000169045-HNRNPH1/tissue","note":"RNA tissue and blood lineage specificity, normal tissue antibody staining (version 25.1, CC BY-SA 3.0)"},{"label":"Open Targets ENSG00000169045 associations","url":"https://platform.opentargets.org/target/ENSG00000169045/associations","note":"cancer associations at or above 0.5 (CC0)"}],"hgnc":"HGNC:5041","ensembl":"ENSG00000169045","uniprot":"P31943","entrez":"3187","firstDescribed":1992,"firstDescribedBasis":"sequence","firstDescribedNote":"Earliest sequence paper UniProt cites for the protein: Rasmussen H.H. et al, Electrophoresis, 1992, \"Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes\".","firstDescribedSource":"https://pubmed.ncbi.nlm.nih.gov/1286667/","biology":"This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Mediates pre-mRNA alternative splicing regulation. Inhibits, together with CUGBP1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Binds to the IR RNA. Binds poly(RG). Location: Nucleus, nucleoplasm (UniProt). Locus 5q35.3 (HGNC).","whereFound":["Mantle cell lymphoma: CIViC evidence names this disease"],"targetClass":"other","prevalence":[]},"route":"/targets/hnrnph1/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"}],"cancer":[{"id":"mantle-cell-lymphoma","kind":"cancer","name":"Mantle cell lymphoma","route":"/cancers/mantle-cell-lymphoma/"}]}}