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HLF (Transcription factor HLF) is a protein that switches other genes on and off. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role.
Transcription factor which selectively binds with high affinity to the consensus sequence 5'-GTTACGTAAT-3' and to closely related sites. Has transcriptional activator activity. Also has transcriptional repressor activity.
Open Targets scores its association with cancer at 0.65 (direct and indirect evidence; datatypes literature 0.90, genetic association 0.20, somatic mutation 0.82).
In plain words · HLF (Transcription factor HLF) is a protein that switches other genes on and off. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role.
HLF (Transcription factor HLF) is a protein that switches other genes on and off. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role.
Transcription factor which selectively binds with high affinity to the consensus sequence 5'-GTTACGTAAT-3' and to closely related sites. Has transcriptional activator activity.
No product in this corpus aims at HLF yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
First described 1992. Earliest sequence paper UniProt cites for the protein: Hunger S.P. et al, Genes Dev, 1992, "Hlf, a novel hepatic bZIP protein, shows altered DNA-binding properties following fusion to E2A in t(17;19) acute lymphoblastic leukemia". Source.
Sources: HGNC HGNC:4977 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q16534 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000108924 (association with cancer (MONDO_0004992) 0.65; (GraphQL API, CC0))
Transcription factor which selectively binds with high affinity to the consensus sequence 5'-GTTACGTAAT-3' and to closely related sites. Has transcriptional activator activity. Also has transcriptional repressor activity. Binds to multiple sites in the promoter regions of coagulation factors F8 and F9 and activates transcription; transactivation activity is enhanced by formation of a heterodimer with DBP. Binds to the promoter region of IRF2 and activates transcription. Maintains quiescence of haematopoietic stem cells under steady-state conditions and protects the stem cell pool from toxic insults. Location: Nucleus (UniProt). Locus 17q22 (HGNC).
Query for this target: (TITLE:"HLF" OR ABSTRACT:"HLF" OR TITLE:"HLF transcription factor, PAR bZIP family member" OR ABSTRACT:"HLF transcription factor, PAR bZIP family member" OR TITLE:"Transcription factor HLF" OR ABSTRACT:"Transcription factor HLF" OR TITLE:"MGC33822" OR ABSTRACT:"MGC33822") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about HLF, not a curated reading list.