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HLF (Transcription factor HLF) is a protein that switches other genes on and off. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Transcription factor which selectively binds with high affinity to the consensus sequence 5'-GTTACGTAAT-3' and to closely related sites. Has transcriptional activator activity. Also has transcriptional repressor activity. Binds to multiple sites in the promoter regions of coagulation factors F8 and F9 and activates transcription; transactivation activity is enhanced by formation of a heterodimer with DBP. Binds to the promoter region of IRF2 and activates transcription. Maintains quiescence of haematopoietic stem cells under steady-state conditions and protects the stem cell pool from toxic insults. Location: Nucleus (UniProt). Locus 17q22 (HGNC).
No product in the corpus is aimed at this target yet.
No trial in the corpus names this target or one of its products.
No recorded escape route names this target.
No pathway diagram carries this target as a node.
No companion diagnostic in the registry measures this target.
No model entry for this target yet; check the cancer entries on the models page.
No open questions recorded for this target yet. Suggest one.
Query for this target: (TITLE:"HLF" OR ABSTRACT:"HLF" OR TITLE:"HLF transcription factor, PAR bZIP family member" OR ABSTRACT:"HLF transcription factor, PAR bZIP family member" OR TITLE:"Transcription factor HLF" OR ABSTRACT:"Transcription factor HLF" OR TITLE:"MGC33822" OR ABSTRACT:"MGC33822") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about HLF, not a curated reading list.
The dossier as machine-readable JSON, at /api/v1/dossiers/hlf.json: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/hlf.json. Licence CC BY-NC 4.0.