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HDAC10 (Polyamine deacetylase HDAC10) is an enzyme. The public catalogues list it as a drug target and a DNA repair gene, and an approved or late-stage drug is recorded against it. Tied to Non-Hodgkin lymphoma and Multiple myeloma.
Polyamine deacetylase (PDAC), which acts preferentially on N(8)-acetylspermidine, and also on acetylcadaverine and acetylputrescine. Exhibits attenuated catalytic activity toward N(1),N(8)-diacetylspermidine and very low activity, if any, toward N(1)-acetylspermidine. Histone deacetylase activity has been observed in vitro.
Open Targets scores its association with cancer at 0.61 (direct and indirect evidence; datatypes literature 0.96, genetic association 0.00, clinical 0.95). In OnCo, 1 product record names it (Tucidinostat (chidamide)).
In plain words · HDAC10 (Polyamine deacetylase HDAC10) is an enzyme. The public catalogues list it as a drug target and a DNA repair gene, and an approved or late-stage drug is recorded against it. Tied to Non-Hodgkin lymphoma and Multiple myeloma.
HDAC10 (Polyamine deacetylase HDAC10) is an enzyme. The public catalogues list it as a drug target and a DNA repair gene, and an approved or late-stage drug is recorded against it. Tied to Non-Hodgkin lymphoma and Multiple myeloma.
Polyamine deacetylase (PDAC), which acts preferentially on N(8)-acetylspermidine, and also on acetylcadaverine and acetylputrescine.
No product in this corpus aims at HDAC10 yet. Inhibitors are shaped to fit the enzyme's active site so the reaction the cancer relies on stops.
Tumour-associated overexpression or amplification: 1 of 1 medicines aimed at it name overexpression or amplification in their mechanism (Tucidinostat (chidamide)). HPA HDAC10: RNA low tissue specificity; high antibody staining in 26 normal tissues; highest cancer staining breast cancer (11 of 12 high). Distribution: 2 cancer families in the corpus carry a prevalence row, label threshold or catalogue link for it (Lymphoma, Multiple myeloma); Open Targets associates it with 2 specific cancer types at or above 0.5 (plasma cell myeloma, peripheral T-cell lymphoma, not otherwise specified). (Rule 4 of scripts/fetch-target-specificity.ts.)
Sources: Chipscreen Biosciences; Human Protein Atlas HDAC10 tissue; Human Protein Atlas HDAC10 pathology; Open Targets ENSG00000100429 associations
First described 1999. Earliest sequence paper UniProt cites for the protein: Dunham et al, Nature, 1999, "The DNA sequence of human chromosome 22". Source.
Sources: HGNC HGNC:18128 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q969S8 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000100429 (association with cancer (MONDO_0004992) 0.61; per-cancer scores at or above 0.5: plasma cell myeloma 0.55, non-Hodgkin lymphoma 0.56 (GraphQL API, CC0))
Polyamine deacetylase (PDAC), which acts preferentially on N(8)-acetylspermidine, and also on acetylcadaverine and acetylputrescine. Exhibits attenuated catalytic activity toward N(1),N(8)-diacetylspermidine and very low activity, if any, toward N(1)-acetylspermidine. Histone deacetylase activity has been observed in vitro. Has also been shown to be involved in MSH2 deacetylation. The physiological relevance of protein/histone deacetylase activity is unclear and could be very weak. May play a role in the promotion of late stages of autophagy, possibly autophagosome-lysosome fusion and/or lysosomal exocytosis in neuroblastoma cells. Location: Cytoplasm; Nucleus (UniProt). Locus 22q13.33 (HGNC).
RNA: low tissue specificity, detected in many normal tissues.
Medium: Adipose tissue, Adrenal gland, Appendix, Bone marrow, Breast, Bronchus, Cervix, Endometrium.
Medium only: lung cancer, stomach cancer, thyroid cancer.
HPA HDAC10 tissue · HPA HDAC10 pathology · HPA protein class: FDA approved drug targets
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"HDAC10" OR ABSTRACT:"HDAC10" OR TITLE:"histone deacetylase 10" OR ABSTRACT:"histone deacetylase 10" OR TITLE:"Polyamine deacetylase HDAC10" OR ABSTRACT:"Polyamine deacetylase HDAC10" OR TITLE:"DKFZP761B039" OR ABSTRACT:"DKFZP761B039") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about HDAC10, not a curated reading list.