{"entity":{"id":"hdac10","kind":"target","name":"HDAC10","aka":["histone deacetylase 10","Polyamine deacetylase HDAC10","DKFZP761B039"],"tldr":"HDAC10 (Polyamine deacetylase HDAC10) is an enzyme. The public catalogues list it as a drug target and a DNA repair gene, and an approved or late-stage drug is recorded against it. Tied to Non-Hodgkin lymphoma and Multiple myeloma.","summary":"Polyamine deacetylase (PDAC), which acts preferentially on N(8)-acetylspermidine, and also on acetylcadaverine and acetylputrescine. Exhibits attenuated catalytic activity toward N(1),N(8)-diacetylspermidine and very low activity, if any, toward N(1)-acetylspermidine. Histone deacetylase activity has been observed in vitro.\n\nOpen Targets scores its association with cancer at 0.61 (direct and indirect evidence; datatypes literature 0.96, genetic association 0.00, clinical 0.95). In OnCo, 1 product record names it (Tucidinostat (chidamide)).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:18128","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:18128"},{"label":"UniProt Q969S8","url":"https://www.uniprot.org/uniprotkb/Q969S8/entry"},{"label":"NCBI Gene 83933","url":"https://www.ncbi.nlm.nih.gov/gene/83933"},{"label":"Ensembl ENSG00000100429","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000100429"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["non-hodgkin-lymphoma","multiple-myeloma"],"sections":[],"technologies":[],"targets":[],"drugs":["tucidinostat"],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.95; UniProt keyword \"DNA repair\". Evidence tier \"approved-drug\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"HDAC10","role":["drug-target","dna-repair"],"evidenceTier":"approved-drug","sources":[{"label":"HGNC HGNC:18128","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:18128","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q969S8","url":"https://www.uniprot.org/uniprotkb/Q969S8/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000100429","url":"https://platform.opentargets.org/target/ENSG00000100429/associations","note":"association with cancer (MONDO_0004992) 0.61; per-cancer scores at or above 0.5: plasma cell myeloma 0.55, non-Hodgkin lymphoma 0.56 (GraphQL API, CC0)"}],"specificity":"tumour-associated","distribution":"few-types","specificityNote":"Tumour-associated overexpression or amplification: 1 of 1 medicines aimed at it name overexpression or amplification in their mechanism (Tucidinostat (chidamide)). HPA HDAC10: RNA low tissue specificity; high antibody staining in 26 normal tissues; highest cancer staining breast cancer (11 of 12 high). Distribution: 2 cancer families in the corpus carry a prevalence row, label threshold or catalogue link for it (Lymphoma, Multiple myeloma); Open Targets associates it with 2 specific cancer types at or above 0.5 (plasma cell myeloma, peripheral T-cell lymphoma, not otherwise specified). (Rule 4 of scripts/fetch-target-specificity.ts.)","specificitySources":[{"label":"Chipscreen Biosciences","url":"https://www.chipscreen.com/en/"},{"label":"Human Protein Atlas HDAC10 tissue","url":"https://www.proteinatlas.org/ENSG00000100429-HDAC10/tissue","note":"RNA tissue and blood lineage specificity, normal tissue antibody staining (version 25.1, CC BY-SA 3.0)"},{"label":"Human Protein Atlas HDAC10 pathology","url":"https://www.proteinatlas.org/ENSG00000100429-HDAC10/pathology","note":"patients per staining level per cancer type (version 25.1, CC BY-SA 3.0)"},{"label":"Open Targets ENSG00000100429 associations","url":"https://platform.opentargets.org/target/ENSG00000100429/associations","note":"cancer associations at or above 0.5 (CC0)"}],"hgnc":"HGNC:18128","ensembl":"ENSG00000100429","uniprot":"Q969S8","entrez":"83933","firstDescribed":1999,"firstDescribedBasis":"sequence","firstDescribedNote":"Earliest sequence paper UniProt cites for the protein: Dunham et al, Nature, 1999, \"The DNA sequence of human chromosome 22\".","firstDescribedSource":"https://pubmed.ncbi.nlm.nih.gov/10591208/","biology":"Polyamine deacetylase (PDAC), which acts preferentially on N(8)-acetylspermidine, and also on acetylcadaverine and acetylputrescine. Exhibits attenuated catalytic activity toward N(1),N(8)-diacetylspermidine and very low activity, if any, toward N(1)-acetylspermidine. Histone deacetylase activity has been observed in vitro. Has also been shown to be involved in MSH2 deacetylation. The physiological relevance of protein/histone deacetylase activity is unclear and could be very weak. May play a role in the promotion of late stages of autophagy, possibly autophagosome-lysosome fusion and/or lysosomal exocytosis in neuroblastoma cells. Location: Cytoplasm; Nucleus (UniProt). Locus 22q13.33 (HGNC).","whereFound":["Non-Hodgkin lymphoma: Open Targets association 0.56 with non-Hodgkin lymphoma (MONDO_0018908)","Multiple myeloma: Open Targets association 0.55 with plasma cell myeloma (MONDO_0009693)"],"targetClass":"enzyme","prevalence":[]},"route":"/targets/hdac10/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"multiple-myeloma","kind":"cancer","name":"Multiple myeloma","route":"/cancers/multiple-myeloma/"},{"id":"non-hodgkin-lymphoma","kind":"cancer","name":"Non-Hodgkin lymphoma (all types)","route":"/cancers/non-hodgkin-lymphoma/"}],"drug":[{"id":"tucidinostat","kind":"drug","name":"Tucidinostat (chidamide)","route":"/drugs/tucidinostat/"}]}}