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H3C4 (Histone H3.1) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response.
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.
CIViC holds 1 clinical evidence item and 0 assertions across 1 variant.
In plain words · H3C4 (Histone H3.1) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response.
H3C4 (Histone H3.1) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response.
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template.
No product in this corpus aims at H3C4 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
Broadly expressed or essential: HPA lists H3C4 among essential proteins; a medicine acting on the wild-type protein would expose normal tissue too. HPA H3C4: RNA tissue enriched (bone marrow 12 nTPM); high antibody staining in 44 normal tissues; highest cancer staining glioma (12 of 12 high). Distribution: no corpus cancer carries a prevalence row, threshold or catalogue link for it; Open Targets associates it with 0 specific cancer types at or above 0.5. (Rule 7 of scripts/fetch-target-specificity.ts.)
Sources: Human Protein Atlas H3C4 tissue; Open Targets ENSG00000197409 associations
First described 1981. Earliest sequence paper UniProt cites for the protein: Ohe et al, J. Biochem, 1981, "Human spleen histone H3. Isolation and amino acid sequence". Source.
Sources: HGNC HGNC:4767 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P68431 (protein name, function text, keywords and locations (REST API)); CIViC gene H3C4 (1 evidence items, 0 assertions, 1 variants; diseases: Posterior Fossa Group A Ependymoma (GraphQL API, CC0))
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Location: Nucleus; Chromosome (UniProt). Locus 6p22.2 (HGNC).
RNA: tissue enriched (bone marrow 12 nTPM), detected in some normal tissues.
Medium: Oral mucosa.
RNA cancer enhanced: Colon Adenocarcinoma 10 pTPM.
HPA H3C4 tissue · HPA H3C4 pathology · HPA protein class: Essential proteins
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"H3C4" OR ABSTRACT:"H3C4" OR TITLE:"H3 clustered histone 4" OR ABSTRACT:"H3 clustered histone 4" OR TITLE:"Histone H3.1" OR ABSTRACT:"Histone H3.1" OR TITLE:"H3/b" OR ABSTRACT:"H3/b" OR TITLE:"H3FB" OR ABSTRACT:"H3FB" OR TITLE:"HIST1H3D" OR ABSTRACT:"HIST1H3D") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about H3C4, not a curated reading list.