{"entity":{"id":"h3c4","kind":"target","name":"H3C4","aka":["H3 clustered histone 4","Histone H3.1","H3/b","H3FB","HIST1H3D"],"tldr":"H3C4 (Histone H3.1) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response.","summary":"Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.\n\nCIViC holds 1 clinical evidence item and 0 assertions across 1 variant.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:4767","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:4767"},{"label":"UniProt P68431","url":"https://www.uniprot.org/uniprotkb/P68431/entry"},{"label":"NCBI Gene 8351","url":"https://www.ncbi.nlm.nih.gov/gene/8351"},{"label":"Ensembl ENSG00000197409","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000197409"}],"tags":["cancer-genes-wave"],"related":["civic"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC holds 1 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate.","Diseases the sources name that have no OnCo cancer page yet, so they are not linked: Posterior Fossa Group A Ependymoma."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"H3C4","role":["biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:4767","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:4767","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P68431","url":"https://www.uniprot.org/uniprotkb/P68431/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene H3C4","url":"https://civicdb.org/features/6607","note":"1 evidence items, 0 assertions, 1 variants; diseases: Posterior Fossa Group A Ependymoma (GraphQL API, CC0)"}],"specificity":"broadly-expressed","distribution":"not-established","specificityNote":"Broadly expressed or essential: HPA lists H3C4 among essential proteins; a medicine acting on the wild-type protein would expose normal tissue too. HPA H3C4: RNA tissue enriched (bone marrow 12 nTPM); high antibody staining in 44 normal tissues; highest cancer staining glioma (12 of 12 high). Distribution: no corpus cancer carries a prevalence row, threshold or catalogue link for it; Open Targets associates it with 0 specific cancer types at or above 0.5. (Rule 7 of scripts/fetch-target-specificity.ts.)","specificitySources":[{"label":"Human Protein Atlas H3C4 tissue","url":"https://www.proteinatlas.org/ENSG00000197409-H3C4/tissue","note":"RNA tissue and blood lineage specificity, normal tissue antibody staining (version 25.1, CC BY-SA 3.0)"},{"label":"Open Targets ENSG00000197409 associations","url":"https://platform.opentargets.org/target/ENSG00000197409/associations","note":"cancer associations at or above 0.5 (CC0)"}],"hgnc":"HGNC:4767","ensembl":"ENSG00000197409","uniprot":"P68431","entrez":"8351","firstDescribed":1981,"firstDescribedBasis":"sequence","firstDescribedNote":"Earliest sequence paper UniProt cites for the protein: Ohe et al, J. Biochem, 1981, \"Human spleen histone H3. Isolation and amino acid sequence\".","firstDescribedSource":"https://pubmed.ncbi.nlm.nih.gov/7309716/","biology":"Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Location: Nucleus; Chromosome (UniProt). Locus 6p22.2 (HGNC).","whereFound":[],"targetClass":"other","prevalence":[]},"route":"/targets/h3c4/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"}]}}