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H3C14 (Histone H3.2) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Diffuse midline glioma, H3 K27-altered.
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.
CIViC holds 1 clinical evidence item and 0 assertions across 1 variant.
In plain words · H3C14 (Histone H3.2) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Diffuse midline glioma, H3 K27-altered.
H3C14 (Histone H3.2) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Diffuse midline glioma, H3 K27-altered.
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template.
No product in this corpus aims at H3C14 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the role biomarker; HPA finds the RNA tissue enhanced, which says where the protein sits but not whether the tumour differs from normal tissue. HPA H3C14: RNA tissue enhanced (bone marrow 1 nTPM, brain 2 nTPM, prostate 2 nTPM); high antibody staining in 44 normal tissues; highest cancer staining glioma (12 of 12 high). Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Brain and spinal cord tumours (all types)); Open Targets associates it with 0 specific cancer types at or above 0.5. (No rule of scripts/fetch-target-specificity.ts fired.)
Sources: Human Protein Atlas H3C14 tissue; Open Targets ENSG00000203811 associations
First described 1981. Earliest sequence paper UniProt cites for the protein: Ohe et al, J. Biochem, 1981, "Human spleen histone H3. Isolation and amino acid sequence". Source.
Sources: HGNC HGNC:20503 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q71DI3 (protein name, function text, keywords and locations (REST API)); CIViC gene H3C14 (1 evidence items, 0 assertions, 1 variants; diseases: Diffuse Midline Glioma, H3 K27-altered (GraphQL API, CC0))
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Location: Nucleus; Chromosome (UniProt). Locus 1q21.2 (HGNC).
RNA: tissue enhanced (bone marrow 1 nTPM, brain 2 nTPM, prostate 2 nTPM, retina 1 nTPM), detected in some normal tissues.
Medium: Oral mucosa.
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"H3C14" OR ABSTRACT:"H3C14" OR TITLE:"H3 clustered histone 14" OR ABSTRACT:"H3 clustered histone 14" OR TITLE:"Histone H3.2" OR ABSTRACT:"Histone H3.2" OR TITLE:"MGC9629" OR ABSTRACT:"MGC9629" OR TITLE:"H3/m" OR ABSTRACT:"H3/m" OR TITLE:"H3" OR ABSTRACT:"H3") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about H3C14, not a curated reading list.