{"entity":{"id":"h3c14","kind":"target","name":"H3C14","aka":["H3 clustered histone 14","Histone H3.2","MGC9629","H3/m","H3","H3.2","H3/M","H3F2","H3FM","HIST2H3C"],"tldr":"H3C14 (Histone H3.2) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Diffuse midline glioma, H3 K27-altered.","summary":"Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.\n\nCIViC holds 1 clinical evidence item and 0 assertions across 1 variant.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:20503","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:20503"},{"label":"UniProt Q71DI3","url":"https://www.uniprot.org/uniprotkb/Q71DI3/entry"},{"label":"NCBI Gene 126961","url":"https://www.ncbi.nlm.nih.gov/gene/126961"},{"label":"Ensembl ENSG00000203811","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000203811"}],"tags":["cancer-genes-wave"],"related":["civic"],"cancers":["dipg-dmg"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC holds 1 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"H3C14","role":["biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:20503","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:20503","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q71DI3","url":"https://www.uniprot.org/uniprotkb/Q71DI3/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene H3C14","url":"https://civicdb.org/features/17939","note":"1 evidence items, 0 assertions, 1 variants; diseases: Diffuse Midline Glioma, H3 K27-altered (GraphQL API, CC0)"}],"distribution":"one-type","specificityNote":"Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the role biomarker; HPA finds the RNA tissue enhanced, which says where the protein sits but not whether the tumour differs from normal tissue. HPA H3C14: RNA tissue enhanced (bone marrow 1 nTPM, brain 2 nTPM, prostate 2 nTPM); high antibody staining in 44 normal tissues; highest cancer staining glioma (12 of 12 high). Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Brain and spinal cord tumours (all types)); Open Targets associates it with 0 specific cancer types at or above 0.5. (No rule of scripts/fetch-target-specificity.ts fired.)","specificitySources":[{"label":"Human Protein Atlas H3C14 tissue","url":"https://www.proteinatlas.org/ENSG00000203811-H3C14/tissue","note":"RNA tissue and blood lineage specificity, normal tissue antibody staining (version 25.1, CC BY-SA 3.0)"},{"label":"Open Targets ENSG00000203811 associations","url":"https://platform.opentargets.org/target/ENSG00000203811/associations","note":"cancer associations at or above 0.5 (CC0)"}],"hgnc":"HGNC:20503","ensembl":"ENSG00000203811","uniprot":"Q71DI3","entrez":"126961","firstDescribed":1981,"firstDescribedBasis":"sequence","firstDescribedNote":"Earliest sequence paper UniProt cites for the protein: Ohe et al, J. Biochem, 1981, \"Human spleen histone H3. Isolation and amino acid sequence\".","firstDescribedSource":"https://pubmed.ncbi.nlm.nih.gov/7309716/","biology":"Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Location: Nucleus; Chromosome (UniProt). Locus 1q21.2 (HGNC).","whereFound":["Diffuse midline glioma, H3 K27-altered: CIViC evidence names this disease"],"targetClass":"other","prevalence":[]},"route":"/targets/h3c14/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"}],"cancer":[{"id":"dipg-dmg","kind":"cancer","name":"Diffuse midline glioma, H3 K27-altered (including DIPG)","route":"/cancers/dipg-dmg/"}]}}