Loading
H2BC12 (Histone H2B type 1-K) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Diffuse large B-cell lymphoma.
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.
CIViC holds 1 clinical evidence item and 0 assertions across 1 variant.
In plain words · H2BC12 (Histone H2B type 1-K) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Diffuse large B-cell lymphoma.
H2BC12 (Histone H2B type 1-K) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Diffuse large B-cell lymphoma.
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template.
No product in this corpus aims at H2BC12 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
Broadly expressed or essential: HPA lists H2BC12 among essential proteins and finds the RNA at low tissue specificity; a medicine acting on the wild-type protein would expose normal tissue too. HPA H2BC12: RNA low tissue specificity; high antibody staining in 44 normal tissues; highest cancer staining glioma (11 of 11 high). Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Lymphoma); Open Targets associates it with 0 specific cancer types at or above 0.5. (Rule 7 of scripts/fetch-target-specificity.ts.)
Sources: Human Protein Atlas H2BC12 tissue; Open Targets ENSG00000197903 associations
First described 1996. Earliest sequence paper UniProt cites for the protein: Frohm et al, Eur. J. Biochem, 1996, "Biochemical and antibacterial analysis of human wound and blister fluid". Source.
Sources: HGNC HGNC:13954 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt O60814 (protein name, function text, keywords and locations (REST API)); CIViC gene H2BC12 (1 evidence items, 0 assertions, 1 variants; diseases: Diffuse Large B-cell Lymphoma (GraphQL API, CC0))
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid. Location: Nucleus; Chromosome (UniProt). Locus 6p22.1 (HGNC).
RNA: low tissue specificity, detected in many normal tissues.
Medium: Smooth muscle.
HPA H2BC12 tissue · HPA H2BC12 pathology · HPA protein class: Essential proteins
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"H2BC12" OR ABSTRACT:"H2BC12" OR TITLE:"H2B clustered histone 12" OR ABSTRACT:"H2B clustered histone 12" OR TITLE:"Histone H2B type 1-K" OR ABSTRACT:"Histone H2B type 1-K" OR TITLE:"H2BFAiii" OR ABSTRACT:"H2BFAiii" OR TITLE:"H2BFT" OR ABSTRACT:"H2BFT" OR TITLE:"HIST1H2BK" OR ABSTRACT:"HIST1H2BK") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about H2BC12, not a curated reading list.