{"entity":{"id":"h2bc12","kind":"target","name":"H2BC12","aka":["H2B clustered histone 12","Histone H2B type 1-K","H2BFAiii","H2BFT","HIST1H2BK"],"tldr":"H2BC12 (Histone H2B type 1-K) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Diffuse large B-cell lymphoma.","summary":"Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.\n\nCIViC holds 1 clinical evidence item and 0 assertions across 1 variant.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:13954","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:13954"},{"label":"UniProt O60814","url":"https://www.uniprot.org/uniprotkb/O60814/entry"},{"label":"NCBI Gene 85236","url":"https://www.ncbi.nlm.nih.gov/gene/85236"},{"label":"Ensembl ENSG00000197903","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000197903"}],"tags":["cancer-genes-wave"],"related":["civic"],"cancers":["dlbcl"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC holds 1 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"H2BC12","role":["biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:13954","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:13954","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt O60814","url":"https://www.uniprot.org/uniprotkb/O60814/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene H2BC12","url":"https://civicdb.org/features/16516","note":"1 evidence items, 0 assertions, 1 variants; diseases: Diffuse Large B-cell Lymphoma (GraphQL API, CC0)"}],"specificity":"broadly-expressed","distribution":"one-type","specificityNote":"Broadly expressed or essential: HPA lists H2BC12 among essential proteins and finds the RNA at low tissue specificity; a medicine acting on the wild-type protein would expose normal tissue too. HPA H2BC12: RNA low tissue specificity; high antibody staining in 44 normal tissues; highest cancer staining glioma (11 of 11 high). Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Lymphoma); Open Targets associates it with 0 specific cancer types at or above 0.5. (Rule 7 of scripts/fetch-target-specificity.ts.)","specificitySources":[{"label":"Human Protein Atlas H2BC12 tissue","url":"https://www.proteinatlas.org/ENSG00000197903-H2BC12/tissue","note":"RNA tissue and blood lineage specificity, normal tissue antibody staining (version 25.1, CC BY-SA 3.0)"},{"label":"Open Targets ENSG00000197903 associations","url":"https://platform.opentargets.org/target/ENSG00000197903/associations","note":"cancer associations at or above 0.5 (CC0)"}],"hgnc":"HGNC:13954","ensembl":"ENSG00000197903","uniprot":"O60814","entrez":"85236","firstDescribed":1996,"firstDescribedBasis":"sequence","firstDescribedNote":"Earliest sequence paper UniProt cites for the protein: Frohm et al, Eur. J. Biochem, 1996, \"Biochemical and antibacterial analysis of human wound and blister fluid\".","firstDescribedSource":"https://pubmed.ncbi.nlm.nih.gov/8620898/","biology":"Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid. Location: Nucleus; Chromosome (UniProt). Locus 6p22.1 (HGNC).","whereFound":["Diffuse large B-cell lymphoma: CIViC evidence names this disease"],"targetClass":"other","prevalence":[]},"route":"/targets/h2bc12/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"}],"cancer":[{"id":"dlbcl","kind":"cancer","name":"Diffuse large B-cell lymphoma","route":"/cancers/dlbcl/"}]}}