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H1-2 (Histone H1.2) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Diffuse large B-cell lymphoma.
Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fibre. Histone H1-2 is required for the condensation of nucleosome chains into higher-order structured fibres. Compared to other histone H1 variants, H1-2 plays an essential role in nucleosome condensation: its absence leads to global chromatin decompaction, which is not observed when depleting other histone H1 variants.
CIViC holds 1 clinical evidence item and 0 assertions across 1 variant.
In plain words · H1-2 (Histone H1.2) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Diffuse large B-cell lymphoma.
H1-2 (Histone H1.2) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Diffuse large B-cell lymphoma.
Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fibre. Histone H1-2 is required for the condensation of nucleosome chains into higher-order structured fibres.
No product in this corpus aims at H1-2 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
Broadly expressed or essential: HPA lists H1-2 among essential proteins and finds the RNA at low tissue specificity; a medicine acting on the wild-type protein would expose normal tissue too. HPA H1-2: RNA low tissue specificity; blood lineage lineage enriched (granulocytes 460 nTPM); high antibody staining in 45 normal tissues; highest cancer staining breast cancer (12 of 12 high). Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Lymphoma); Open Targets associates it with 0 specific cancer types at or above 0.5. (Rule 7 of scripts/fetch-target-specificity.ts.)
Sources: Human Protein Atlas H1-2 tissue; Open Targets ENSG00000187837 associations
First described 1989. Earliest sequence paper UniProt cites for the protein: Eick et al, Eur. J. Cell Biol, 1989, "Human H1 histones: conserved and varied sequence elements in two H1 subtype genes". Source.
Sources: HGNC HGNC:4716 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P16403 (protein name, function text, keywords and locations (REST API)); CIViC gene H1-2 (1 evidence items, 0 assertions, 1 variants; diseases: Diffuse Large B-cell Lymphoma (GraphQL API, CC0))
Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fibre. Histone H1-2 is required for the condensation of nucleosome chains into higher-order structured fibres. Compared to other histone H1 variants, H1-2 plays an essential role in nucleosome condensation: its absence leads to global chromatin decompaction, which is not observed when depleting other histone H1 variants. Histone H1-2 also acts as a histone reader: specifically recognises and binds histone H3 trimethylated at 'lys-27' (H3K27me3). Histones H1 also promote formation of the H3K27me3 mark by the PRC2/EED-EZH2 complex, possibly by facilitating restoration of H3K27me3 post-replication. Together with histone H1-3, histone H1-2 acts as a regulator of splicing, most specifically exon skipping and intron retention events: histone H1-2 has a high affinity for exons and regulates splicing by affecting RNA polymerase II (RNAPII) elongation. Location: Nucleus; Nucleus, nucleolus; Chromosome (UniProt). Locus 6p22.2 (HGNC).
RNA: low tissue specificity, detected in all normal tissues. Blood: lineage enriched (granulocytes 460 nTPM).
HPA H1-2 tissue · HPA H1-2 pathology · HPA protein class: Essential proteins
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"H1-2" OR ABSTRACT:"H1-2" OR TITLE:"H1.2 linker histone, cluster member" OR ABSTRACT:"H1.2 linker histone, cluster member" OR TITLE:"Histone H1.2" OR ABSTRACT:"Histone H1.2" OR TITLE:"H1.2" OR ABSTRACT:"H1.2" OR TITLE:"H1s-1" OR ABSTRACT:"H1s-1" OR TITLE:"H1c" OR ABSTRACT:"H1c") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about H1-2, not a curated reading list.