Loading
GSTP1 (Glutathione S-transferase P) is an enzyme. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Colorectal cancer and Ovarian cancer.
Catalyses conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2). Participates in the formation of novel hepoxilin regioisomers.
CIViC holds 2 clinical evidence items and 0 assertions across 3 variants, naming Paclitaxel, Carboplatin, Cisplatin and FOLFOX Regimen.
In plain words · GSTP1 (Glutathione S-transferase P) is an enzyme. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Colorectal cancer and Ovarian cancer.
GSTP1 (Glutathione S-transferase P) is an enzyme. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Colorectal cancer and Ovarian cancer.
Catalyses conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2).
No product in this corpus aims at GSTP1 yet. Inhibitors are shaped to fit the enzyme's active site so the reaction the cancer relies on stops.
Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the roles drug-target, biomarker; HPA finds the RNA tissue enhanced, which says where the protein sits but not whether the tumour differs from normal tissue. HPA GSTP1: RNA tissue enhanced (esophagus 2,859 nTPM); high antibody staining in 8 normal tissues; highest cancer staining breast cancer (1 of 11 high). Distribution: 2 cancer families in the corpus carry a prevalence row, label threshold or catalogue link for it (Colorectal cancer, Ovarian cancer); Open Targets associates it with 0 specific cancer types at or above 0.5. (No rule of scripts/fetch-target-specificity.ts fired.)
Sources: Human Protein Atlas GSTP1 tissue; Open Targets ENSG00000084207 associations
First described 1985. Earliest sequence paper UniProt cites for the protein: Alin et al, FEBS Lett, 1985, "Structural evidence for three different types of glutathione transferase in human tissues". Source.
Sources: HGNC HGNC:4638 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P09211 (protein name, function text, keywords and locations (REST API)); CIViC gene GSTP1 (2 evidence items, 0 assertions, 3 variants; diseases: Colorectal Cancer, Ovarian Carcinoma (GraphQL API, CC0))
Catalyses conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2). Participates in the formation of novel hepoxilin regioisomers. Acts as a negative regulator of ferroptosis by mediating glutathione conjugation and detoxification of 4-hydroxynonenal (4-HNE) reactive aldehyde. Negatively regulates CDK5 activity via p25/p35 translocation to prevent neurodegeneration. Location: Cytoplasm; Mitochondrion; Nucleus (UniProt). Locus 11q13.2 (HGNC).
RNA: tissue enhanced (esophagus 2,859 nTPM), detected in all normal tissues.
Medium: Adrenal gland, Cerebral cortex, Cervix, Endometrium, Esophagus, Gallbladder, Hippocampus, Kidney.
Medium only: cervical cancer, colorectal cancer, head and neck cancer, liver cancer.
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"GSTP1" OR ABSTRACT:"GSTP1" OR TITLE:"glutathione S-transferase pi 1" OR ABSTRACT:"glutathione S-transferase pi 1" OR TITLE:"Glutathione S-transferase P" OR ABSTRACT:"Glutathione S-transferase P" OR TITLE:"FAEES3" OR ABSTRACT:"FAEES3" OR TITLE:"GST3" OR ABSTRACT:"GST3") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about GSTP1, not a curated reading list.