{"entity":{"id":"gstp1","kind":"target","name":"GSTP1","aka":["glutathione S-transferase pi 1","Glutathione S-transferase P","FAEES3","GST3"],"tldr":"GSTP1 (Glutathione S-transferase P) is an enzyme. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Colorectal cancer and Ovarian cancer.","summary":"Catalyses conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2). Participates in the formation of novel hepoxilin regioisomers.\n\nCIViC holds 2 clinical evidence items and 0 assertions across 3 variants, naming Paclitaxel, Carboplatin, Cisplatin and FOLFOX Regimen.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:4638","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:4638"},{"label":"UniProt P09211","url":"https://www.uniprot.org/uniprotkb/P09211/entry"},{"label":"NCBI Gene 2950","url":"https://www.ncbi.nlm.nih.gov/gene/2950"},{"label":"Ensembl ENSG00000084207","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000084207"}],"tags":["cancer-genes-wave"],"related":["civic"],"cancers":["colorectal","ovarian"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 4 therapies; CIViC holds 2 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"GSTP1","role":["drug-target","biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:4638","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:4638","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P09211","url":"https://www.uniprot.org/uniprotkb/P09211/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene GSTP1","url":"https://civicdb.org/features/2473","note":"2 evidence items, 0 assertions, 3 variants; diseases: Colorectal Cancer, Ovarian Carcinoma (GraphQL API, CC0)"}],"distribution":"few-types","specificityNote":"Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the roles drug-target, biomarker; HPA finds the RNA tissue enhanced, which says where the protein sits but not whether the tumour differs from normal tissue. HPA GSTP1: RNA tissue enhanced (esophagus 2,859 nTPM); high antibody staining in 8 normal tissues; highest cancer staining breast cancer (1 of 11 high). Distribution: 2 cancer families in the corpus carry a prevalence row, label threshold or catalogue link for it (Colorectal cancer, Ovarian cancer); Open Targets associates it with 0 specific cancer types at or above 0.5. (No rule of scripts/fetch-target-specificity.ts fired.)","specificitySources":[{"label":"Human Protein Atlas GSTP1 tissue","url":"https://www.proteinatlas.org/ENSG00000084207-GSTP1/tissue","note":"RNA tissue and blood lineage specificity, normal tissue antibody staining (version 25.1, CC BY-SA 3.0)"},{"label":"Open Targets ENSG00000084207 associations","url":"https://platform.opentargets.org/target/ENSG00000084207/associations","note":"cancer associations at or above 0.5 (CC0)"}],"hgnc":"HGNC:4638","ensembl":"ENSG00000084207","uniprot":"P09211","entrez":"2950","firstDescribed":1985,"firstDescribedBasis":"sequence","firstDescribedNote":"Earliest sequence paper UniProt cites for the protein: Alin et al, FEBS Lett, 1985, \"Structural evidence for three different types of glutathione transferase in human tissues\".","firstDescribedSource":"https://pubmed.ncbi.nlm.nih.gov/3979555/","biology":"Catalyses conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2). Participates in the formation of novel hepoxilin regioisomers. Acts as a negative regulator of ferroptosis by mediating glutathione conjugation and detoxification of 4-hydroxynonenal (4-HNE) reactive aldehyde. Negatively regulates CDK5 activity via p25/p35 translocation to prevent neurodegeneration. Location: Cytoplasm; Mitochondrion; Nucleus (UniProt). Locus 11q13.2 (HGNC).","whereFound":["Colorectal cancer: CIViC evidence names this disease","Ovarian cancer: CIViC evidence names this disease"],"targetClass":"enzyme","prevalence":[]},"route":"/targets/gstp1/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"}],"cancer":[{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"},{"id":"ovarian","kind":"cancer","name":"Ovarian cancer","route":"/cancers/ovarian/"}]}}