Loading
GAS6 (Growth arrest-specific protein 6) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Prostate cancer.
Ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signalling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signalling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signalling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. Plays a role in Dengue cell entry by apoptotic mimicry.
CIViC holds 2 clinical evidence items and 0 assertions across 1 variant, naming Docetaxel.
In plain words · GAS6 (Growth arrest-specific protein 6) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Prostate cancer.
GAS6 (Growth arrest-specific protein 6) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Prostate cancer.
Ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signalling is implicated in cell growth and survival, cell adhesion and cell migration.
No product in this corpus aims at GAS6 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the roles drug-target, biomarker; HPA finds the RNA tissue enriched, which says where the protein sits but not whether the tumour differs from normal tissue. HPA GAS6: RNA tissue enriched (blood vessel 838 nTPM); blood lineage lineage enriched (dendritic cells 71 nTPM); no normal tissue stained high; highest cancer staining thyroid cancer (1 of 4 high). Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Prostate cancer); Open Targets associates it with 0 specific cancer types at or above 0.5. (No rule of scripts/fetch-target-specificity.ts fired.)
Sources: Human Protein Atlas GAS6 tissue; Open Targets ENSG00000183087 associations
First described 1993. Earliest sequence paper UniProt cites for the protein: Manfioletti et al, Mol. Cell. Biol, 1993, "The protein encoded by a growth arrest-specific gene (gas6) is a new member of the vitamin K-dependent proteins related to protein S, a negative coregulator in the blood coagulation cascade". Source.
Sources: HGNC HGNC:4168 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q14393 (protein name, function text, keywords and locations (REST API)); CIViC gene GAS6 (2 evidence items, 0 assertions, 1 variants; diseases: Prostate Cancer, Oral Squamous Cell Carcinoma (GraphQL API, CC0))
Ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signalling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signalling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signalling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. Plays a role in Dengue cell entry by apoptotic mimicry. Plays a role in Vaccinia virus cell entry by apoptotic mimicry. Plays a role in ebolavirus and marburgvirus cell entry by apoptotic mimicry. Location: Secreted (UniProt). Locus 13q34 (HGNC).
RNA: tissue enriched (blood vessel 838 nTPM), detected in all normal tissues. Blood: lineage enriched (dendritic cells 71 nTPM).
No normal tissue stained high.
Medium only: colorectal cancer, ovarian cancer, pancreatic cancer.
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"GAS6" OR ABSTRACT:"GAS6" OR TITLE:"growth arrest specific 6" OR ABSTRACT:"growth arrest specific 6" OR TITLE:"Growth arrest-specific protein 6" OR ABSTRACT:"Growth arrest-specific protein 6" OR TITLE:"FLJ34709" OR ABSTRACT:"FLJ34709" OR TITLE:"DKFZp666G247" OR ABSTRACT:"DKFZp666G247" OR TITLE:"AXLLG" OR ABSTRACT:"AXLLG") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about GAS6, not a curated reading list.