{"entity":{"id":"gas6","kind":"target","name":"GAS6","aka":["growth arrest specific 6","Growth arrest-specific protein 6","FLJ34709","DKFZp666G247","AXLLG"],"tldr":"GAS6 (Growth arrest-specific protein 6) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Prostate cancer.","summary":"Ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signalling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signalling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signalling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. Plays a role in Dengue cell entry by apoptotic mimicry.\n\nCIViC holds 2 clinical evidence items and 0 assertions across 1 variant, naming Docetaxel.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:4168","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:4168"},{"label":"UniProt Q14393","url":"https://www.uniprot.org/uniprotkb/Q14393/entry"},{"label":"NCBI Gene 2621","url":"https://www.ncbi.nlm.nih.gov/gene/2621"},{"label":"Ensembl ENSG00000183087","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000183087"}],"tags":["cancer-genes-wave"],"related":["civic"],"cancers":["prostate"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 1 therapies; CIViC holds 2 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate.","Diseases the sources name that have no OnCo cancer page yet, so they are not linked: Oral Squamous Cell Carcinoma."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"GAS6","role":["drug-target","biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:4168","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:4168","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q14393","url":"https://www.uniprot.org/uniprotkb/Q14393/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene GAS6","url":"https://civicdb.org/features/2186","note":"2 evidence items, 0 assertions, 1 variants; diseases: Prostate Cancer, Oral Squamous Cell Carcinoma (GraphQL API, CC0)"}],"distribution":"one-type","specificityNote":"Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the roles drug-target, biomarker; HPA finds the RNA tissue enriched, which says where the protein sits but not whether the tumour differs from normal tissue. HPA GAS6: RNA tissue enriched (blood vessel 838 nTPM); blood lineage lineage enriched (dendritic cells 71 nTPM); no normal tissue stained high; highest cancer staining thyroid cancer (1 of 4 high). Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Prostate cancer); Open Targets associates it with 0 specific cancer types at or above 0.5. (No rule of scripts/fetch-target-specificity.ts fired.)","specificitySources":[{"label":"Human Protein Atlas GAS6 tissue","url":"https://www.proteinatlas.org/ENSG00000183087-GAS6/tissue","note":"RNA tissue and blood lineage specificity, normal tissue antibody staining (version 25.1, CC BY-SA 3.0)"},{"label":"Open Targets ENSG00000183087 associations","url":"https://platform.opentargets.org/target/ENSG00000183087/associations","note":"cancer associations at or above 0.5 (CC0)"}],"hgnc":"HGNC:4168","ensembl":"ENSG00000183087","uniprot":"Q14393","entrez":"2621","firstDescribed":1993,"firstDescribedBasis":"sequence","firstDescribedNote":"Earliest sequence paper UniProt cites for the protein: Manfioletti et al, Mol. Cell. Biol, 1993, \"The protein encoded by a growth arrest-specific gene (gas6) is a new member of the vitamin K-dependent proteins related to protein S, a negative coregulator in the blood coagulation cascade\".","firstDescribedSource":"https://pubmed.ncbi.nlm.nih.gov/8336730/","biology":"Ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signalling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signalling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signalling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. Plays a role in Dengue cell entry by apoptotic mimicry. Plays a role in Vaccinia virus cell entry by apoptotic mimicry. Plays a role in ebolavirus and marburgvirus cell entry by apoptotic mimicry. Location: Secreted (UniProt). Locus 13q34 (HGNC).","whereFound":["Prostate cancer: CIViC evidence names this disease"],"targetClass":"other","prevalence":[]},"route":"/targets/gas6/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"}],"cancer":[{"id":"prostate","kind":"cancer","name":"Prostate cancer","route":"/cancers/prostate/"}]}}